MULTIVALENT SYSTEMS FOR NANOMEDICINE
Group Leader: Miriam Royo
Chemical Multivalent Systems are molecules containing multiple functional groups disposed on spatial distributions that are directly associated to their skeleton/scaffold architecture. These functional groups can be modified, in a controlled manner, with diverse biomolecules, drugs or ligands. Due to this versatility, multivalent systems become chemical tools with great potential in areas as chemical biology and nanomedicine, such as drug delivery, diagnosis and biomaterials.
Our group explore the use of diverse types of chemical multivalent platforms (oligomers, dendrimers, polymers, micelles and lipid nanovesicles), in:
-the generation of multivalent ligands to study GPCR oligomerization; and
-the development of drug delivery systems for colorectal and breast cancer treatment, protein delivery systems for the treatment of lysosomal diseases and macromolecular compounds that have intrinsically therapeutic properties with application to central nervous system diseases.
We also explore the use of different targeting moieties (peptides, small molecules) or transporters to improve the accumulation of these delivery systems of therapeutic agents on specific cells, tissue or organs, or to facilitate the entry through biological barriers as blood brain barrier.
Design and synthesis of biocompatible multivalent systems, as dendrimers, and the study of their applications in biomedicine and chemical biology.
Dendrimers are compounds intrinsically multivalent. Our group has developed several families of biocompatible dendrimers based on polyproline sequences or oligoethylene glycol-DTPA (OEG-DPTA) moieties. These dendrimers can be easily modified at the functional groups of their surface. We have also developed a synthetic method to generate multimodal oligoethylene-DTPA based dendrimers or multivalent platforms in precise and controlled manner. We have explored the use of these dendrimer on different applications, as biomaterials functionalization and gene delivery among others.
Bivalent and multivalent ligands as pharmacological and therapeutic tools for the study of GPCR oligomerization, specifically A2AR, D2R, A1R and D1R oligomerization. Application to the development of a novel treatment for movement disorders, as Parkinson’s syndrome, spinal cord injury and restless legs syndrome.
GPCRs are involved in the regulation of many physiological processes and it is now widely accepted that these receptors form, in addition to functional monomers, dimers and higher-order oligomers. The relevance of these oligomers is that they present functional properties different from those of the constituent monomers and this makes them potential new therapeutic targets. Our group is focused on the development of chemical tools to study the oligomerization of adenosine and dopamine receptors, specifically A2AR-D2R y A1R-D1R oligomers, involved in movement disorders associated with diseases such as Parkinson, spinal cord injuries or restless legs syndrome. Mainly we are working in the design and synthesis of several multivalent platforms (bi-, tri- and tetravalent), functionalized with ligands, both agonists and antagonists, to be used as chemical tools that allow the characterization of these receptors and the evaluation of their potential therapeutic efficacy in the abovementioned pathologies.
Targeted and non-targeted drug-delivery systems for mono and combination therapy for the treatment of advanced colorectal cancer and triple negative breast cancer.
Tumors display a heterogeneous population of cells and among these are the cancer stem-like cells (CSC). Some models suggest that these cells, with self-renewal and multi-lineage differentiation capacities, are the main responsible for metastases and relapses. For this reason, classical chemotherapy, mainly directed to primary tumor cells, is sometimes not enough for the treatment of some types of cancer. The presence of CSC has been described in a variety of cancers, such as breast cancer and colorectal cancer. Our group explore the use of multivalent platforms based on polyglutamic acid-drug conjugates and drug-oligoethylene glycol micelles as drug delivery systems for the treatment of advanced colorectal cancer (mCRC) and triple negative breast cancer (TNBC). The aim is to prepare drug delivery systems containing a combination of different drugs, directed to both primary tumor cells and CSC. Furthermore, targeting molecules (peptides, metabolites) will be incorporated to these platforms to enhance their accumulation in tumor tissues.
Targeting moiety-cholesterol-PEG hybrids as components of lipid nanoparticles. Application to the development of a protein delivery system for Fabry’s disease.
Lipid nanovesicles (LN) are adequate drug delivery systems for different types of drugs. Their surface modification with targeting moieties or other biomolecules usually is performed once nanovesicle is formed being difficult to control. An alternative is to generate LN with components that already contain the targeting moiety. In the frame of an HORIZON 2020 project, SMART-4-FABRY, our group has developed the synthesis of cholesterol-PEG- biomolecules hybrid (Chol-PEG-B) s with different length PEGs to be used as component of protein lipid-based nanoformulation for treatment a Fabry’s disease. These units are generated in high yield and purity and are highly monodisperse. These Chol-PEG-B can be modified with different types of biomolecules, as peptide ligands or sugars, to be used as components to generate different targeting-LN.
Transporter based on peptidomimetics or peptides with the ability to cross biological barriers, as cell membrane and blood brain barrier. Peptide and small molecule ligands as targeting moieties for different applications.
We have developed a new family of g-peptides based on cis-4-amino-proline oligomers that have the ability to cross cell membranes. We are also studying the capacity of these compounds to act as transporters with the ability to cross biological barriers, as blood brain barrier. Furthermore, the intrinsic therapeutic ability of these compounds is also explored for some neurological diseases as Alzheimer and spinal cord injury.
Our group have also developed several peptide and small molecule ligands as targeting units for different diseases
Scientific staff
Miriam Royo
Scientific Researcher
miriam.royo@iqac.csic.es
Daniel Pulido
Scientific Researcher
daniel.pulido@iqac.csic.es
Lab people
Marina Pérez
Postdoctoral Researcher
marina.perez@iqac.csic.es
Sergio de la Hoz
Postdoctoral researcher
sergio.delahoz@iqac.csic.es
Gerardo Acosta
CIBER Technician
gerardo.acosta@iqac.csic.es
Elena Peral
Predoctoral researcher
elena.peral@iqac.csic.es
Emma Reig
Predoctoral researcher
emma.reig@iqac.csic.es
- Peptide-Drug Conjugate for Therapeutic Reprogramming of Tumor-Associated Macrophages in Breast Cancer-
Lepland, Anni, Peranzoni, Elisa, Haljasorg, Uku, Asciutto, Eliana K., Crespí-Amer, Maria, Modesti, Lorenzo, Kilk, Kalle, Lombardia, Manuel, Acosta, Gerardo, Royo, Miriam, Peterson, Pärt, Ilaria
Advanced Science, 2025 - Targeted nanoliposomes to improve enzyme replacement therapy of Fabry disease-
Tomsen-Melero, Judit, Moltó-Abad, Marc, Merlo-Mas, Josep, Díaz-Riascos, Zamira V., Cristóbal-Lecina, Edgar, Soldevila, Andreu, Altendorfer-Kroath, Thomas, Danino, Dganit, Ionita, Inbal, Andersen, Jan Skov, Snelling, Lyndsey, Clay, Hazel, Carreño, Aida, Corchero, José L., Pulido, Daniel, Casas, Josefina, Veciana, Jaume, Schwartz, Simó, Sala, Santi, Font, Albert, Birngruber, Thomas, Royo, Miriam, Córdoba, Alba, Ventosa, Nora, Abasolo, Ibane, González-Mira, Elisabet
Science Advances, Vol 10, Issue 5013, 2024, Article number eadq4738
- Impact of N-Terminal PEGylation on Synthesis and Purification of Peptide-Based Cancer Epitopes for Pancreatic Ductal Adenocarcinoma (PDAC)-
Omar F. LunaYomkippur V. PerezDaniele P. FerrariSana S. SayedipourMiriam RoyoGerardo A. AcostaLuis J. CruzFrauke AlvesErik AgnerMagne O. Sydnes Fernando Albericio
ACS Omega 2024, 9, 32, 34544–34554 - Protocol for Facile Synthesis of Fmoc-N-Me-AA-OH Using 2-CTC Resin as Temporary and Reusable Protecting Group-
Román, T., Acosta, G., Cárdenas, C., de la Torre, B.G., Guzmán, F., Albericio, F.
Methods and Protocols, 6 (6), art. no. 110, 2023 - An experimental and computational investigation of the elusive anhydrous form of Oxyma--
Prohens, R., Barbas, R., de la Torre, B.G., Albericio, F., Frontera, A.
CrystEngComm, 25 (41), pp. 5818-5826, 2024.
- Improving 2-Chlorotrityl Chloride (2-CTC) Resin Activation-
Román, T., Acosta, G., de la Torre, B.G., Cárdenas, C., Guzmán, F., Albericio, F.
Methods and Protocols, 6 (5), art. no. 82, 2023 - Pharmacological activation of insulin-degrading enzyme improves insulin secretion and glucose tolerance in diet-induced obese mice-
Sanz-González, A., Cózar-Castellano, I., Broca, C., Sabatier, J., Acosta, G.A., Royo, M., Hernándo-Muñoz, C., Torroba, T., Perdomo, G., Merino, B.
Diabetes, Obesity and Metabolism, 25 (11), pp. 3268-3278. 2023.
- Design and Synthesis of Peptides from Phoneutria nigriventer δ-Ctenitoxin-Pn2a for Antivenom Production-
Rodríguez, J.A., Barredo-Vacchelli, G.R., Iglesias-García, L.C., Birocco, A.M., Blachman, A., Calabrese, G.C., Acosta, G., Albericio, F., Camperi, S.A.
International Journal of Peptide Research and Therapeutics, 29 (2), art. no. 25, 2023
- Synthesis of [60]Fullerene Hybrids Endowed with Steroids and Monosaccharides: Theoretical Underpinning as Promising anti-SARS-CoV-2 Agents-
Lemos, R., Makowski, K., Almagro, L., Tolón, B., Rodríguez, H., Herranz, M.Á., Molero, D., Martín, N., Suárez, M.
European Journal of Organic Chemistry, 26 (7), art. no. e202201301, 2023.
- Advances in solid-phase peptide synthesis in aqueous media (ASPPS)-
Jaradat, D.M.M., Al Musaimi, O., Albericio, F.
Green Chemistry, 2022
- Solid-Phase Synthesis of an "Inaccessible" hGH-Derived Peptide Using a Pseudoproline Monomer and SIT-Protection for Cysteine-
Manne, S.R., Chakraborty, A., Rustler, K., Bruckdorfer, T., De La Torre, B.G., Albericio, F.
ACS Omega, 2022
- Marine Arthropods as a Source of Antimicrobial Peptides-
Saucedo-Vázquez, J.P., Gushque, F., Vispo, N.S., Rodriguez, J., Gudiño-Gomezjurado, M.E., Albericio, F., Tellkamp, M.P., Alexis, F.
Marine drugs, 20 (8), 2022
- Novel CA(1-7)M(2-9) Analogs: Synthesis, Characterization, and Antibacterial Evaluation-
Chetty, T., Mhlongo, J.T., Waddad, A.Y., Albericio, F., de la Torre, B.G.
ACS Medicinal Chemistry Letters, 2022
- tert-Butylethylcarbodiimide as an Efficient Substitute for Diisopropylcarbodiimide in Solid-Phase Peptide Synthesis: Understanding the Side Reaction of Carbodiimides with OxymaPure-
Manne, S.R., Akintayo, D.C., Luna, O., El-Faham, A., De La Torre, B.G., Albericio, F.
Organic Process Research and Development, 2022
- Solid-Phase Peptide Synthesis Using a Four-Dimensional (Safety-Catch) Protecting Group Scheme-
Noki, S., Brasil, E., Zhang, H., Bruckdorfer, T., De La Torre, B.G., Albericio, F.
Journal of Organic Chemistry, 87 (15), pp. 9443-9453. 2022
- Active targeting of CD4+T lymphocytes by PEI-capped, peptide-functionalized gold nanoparticles-
Ncobeni, N., De La Torre, B.G., Albericio, F., Kruger, H.G., Parboosing, R.
Nanotechnology, 33 (40), art. no. 405101, 2022
- 2-Methoxy-4-methylsulfinylbenzyl Alcohol as a Safety-Catch Linker for the Fmoc/ tBu Solid-Phase Peptide Synthesis Strategy-
Nandhini, K.P., Albericio, F., De La Torre, B.G.
Journal of Organic Chemistry, 87 (15), pp. 9433-9442. 2022
- Synthesis and Antiproliferative Activity of a New Series of Mono- A nd Bis(dimethylpyrazolyl)-s-triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades-
Shawish, I., Barakat, A., Aldalbahi, A., Malebari, A.M., Nafie, M.S., Bekhit, A.A., Albohy, A., Khan, A., Ul-Haq, Z., Haukka, M., De La Torre, B.G., Albericio, F., El-Faham, A.
ACS Omega, 7 (28), pp. 24858-24870. 2022
- Morphological behavior of fullerene-steroid hybrid derivatives-
Lemos, R., Ortiz, F., Almagro, L., Makowski, K., Martin, N., Albericio, F., Suárez, M., Rodríguez, H.
Surface and Interface Analysis, 2022
- Chemical Conjugation in Drug Delivery Systems-
Eras, A., Castillo, D., Suárez, M., Vispo, N.S., Albericio, F., Rodriguez, H.
Journal of Drug Delivery Science and Technology, 72, art. no. 103427, 2022
- In situ Fmoc removal - a sustainable solid-phase peptide synthesis approach-
Kumar, A., Sharma, A., de la Torre, B.G., Albericio, F.
Green Chemistry, 2022
- Amino-Li-Resin—A Fiber Polyacrylamide Resin for Solid-Phase Peptide Synthesis-
Akintayo, D.C., de la Torre, B.G., Li, Y., Albericio, F.
Polymers, 14 (5), art. no. 928, 2022
- Direct Quantitative Immunochemical Analysis of Autoinducer Peptide IV for Diagnosing and Stratifying Staphylococcus aureus Infections-
Enrique-J. Montagut, Gerardo Acosta, Fernando Albericio, Miriam Royo, Gerard Godoy-Tena, Alicia Lacoma, Cristina Prat, Juan-Pablo Salvador, and María-Pilar Marco
ACS Infect. Dis. 2022
- 2021 FDA TIDES (Peptides and Oligonucleotides) Harvest-
Al Shaer, D., Al Musaimi, O., Albericio, F., de la Torre, B.G.
Pharmaceuticals, 15 (2), art. no. 222, 2022
- Linkers: An Assurance for Controlled Delivery of Antibody-Drug Conjugate-
Sheyi, R., de la Torre, B.G., Albericio, F.
Pharmaceutics, 14 (2), art. no. 396, 2022
- Understanding OxymaPure as a Peptide Coupling Additive: A Guide to New Oxyma Derivatives-
Manne, S.R., Sharma, A., Sazonovas, A., El-Faham, A., de la Torre, B.G., Albericio, F.
ACS Omega, 7 (7), pp. 6007-6023. 2022
- The Pharmaceutical Industry in 2021. An Analysis of FDA Drug Approvals from the Perspective of Molecules-
de la Torre, B.G., Albericio, F.
Molecules, 27 (3), art. no. 1075, 2022
- Polyhydroxylated Cyclopentane β-Amino Acids Derived from d-Mannose and d-Galactose: Synthesis and Protocol for Incorporation into Peptides-
Fernández, F., Fernández, A.G., Balo, R., Sánchez-Pedregal, V.M., Royo, M., Soengas, R.G., Estévez, R.J., Estévez, J.C.
ACS Omega, 7 (2), pp. 2002-2014, 2022
- Heterobivalent Ligand for the Adenosine A2A–Dopamine D2 Receptor Heteromer-
Daniel Pulido, Verònica Casadó-Anguera, Marc Gómez-Autet, Natàlia Llopart, Estefanía Moreno, Nil Casajuana-Martin, Sergi Ferré, Leonardo Pardo*, Vicent Casadó, and Miriam Royo
J. Med. Chem. 2022, 65, 1, 616–632
- Chemoselective Disulfide Formation by Thiol-Disulfide Interchange in SIT-Protected Cysteinyl Peptides-
Chakraborty, A., Albericio, F., De La Torre, B.G.
Journal of Organic Chemistry, 87 (1), pp. 708-712. 2022
- Minimizing side reactions during amide formation using DIC and oxymapure in solid-phase peptide synthesis-
Manne, S.R., El-Faham, A., de la Torre, B.G., Albericio, F.
Tetrahedron Letters, 85, art. no. 153462, 2021
- Tuning the cytotoxicity of bis-phosphino-amines ruthenium(Ii) para-cymene complexes for clinical development in breast cancer-
Domínguez-Jurado, E., Cimas, F.J., Castro-Osma, J.A., Juan, A., Lara-Sánchez, A., Rodríguez-Diéguez, A., Shafir, A., Ocaña, A., Alonso-Moreno, C.
Pharmaceutics, 13 (10), art. no. 1559, 2021
- Evaluation of the tert-butyl group as a probe for NMR studies of macromolecular complexes-
Voleti, R., Bali, S., Guerrero, J., Smothers, J., Springhower, C., Acosta, G.A., Brewer, K.D., Albericio, F., Rizo, J.
Journal of Biomolecular NMR, .2021
- Amide Formation: Choosing the Safer Carbodiimide in Combination with OxymaPure to Avoid HCN Release-
Manne, S.R., Luna, O., Acosta, G.A., Royo, M., El-Faham, A., Orosz, G., De La Torre, B.G., Albericio, F.
Organic Letters, 2021
- Rhodiasolv PolarClean–a greener alternative in solid-phase peptide synthesis-
Kumar, A., Sharma, A., de la Torre, B.G., Albericio, F.
Green Chemistry Letters and Reviews, 14 (3), pp. 544-549. 2021
- Tea bags for fmoc solid-phase peptide synthesis: An example of circular economy-
Guzmán, F., Gauna, A., Roman, T., Luna, O., Álvarez, C., Pareja-Barrueto, C., Mercado, L., Albericio, F., Cárdenas, C.
Molecules, 26 (16), art. no. 5035, .
- Synthesis of New Peptide-Based Ligands with 1,2-HOPO Pendant Chelators and Thermodynamic Evaluation of Their Iron(III) Complexes-
Al Shaer, D.M., Albericio, F., de la Torre, B.G.
ChemistrySelect, 6 (30), pp. 7674-7681.
- Fully Automated Screening of a Combinatorial Library to Avoid False Positives: Application to Tetanus Toxoid Ligand Identification-
Martínez Ceron, M.C., Ávila, L., Giudicessi, S.L., Minoia, J.M., Fingermann, M., Camperi, S.A., Albericio, F., Cascone, O.
ACS Omega, 6 (29), pp. 18756-18762, 2021
- Scope and Limitations of Barbituric and Thiobarbituric Amino Acid Derivatives as Protecting Groups for Solid-Phase Peptide Synthesis: Towards a Green Protecting Group-
Ramkisson, S., Al-Rasheed, H.H., Dahlous, K.A., De La Torre, B.G., El-Faham, A., Albericio, F.
ChemistrySelect, 6 (26), pp. 6626-6630. 2021
- Super-cationic peptide dendrimers—synthesis and evaluation as antimicrobial agents-
Ramchuran, E.J., Pérez-Guillén, I., Bester, L.A., Khan, R., Albericio, F., Viñas, M., de la Torre, B.G.
Antibiotics, 10 (6), art. no. 695, 2021
- Hybrid cyclobutane/proline-containing peptidomimetics: The conformational constraint influences their cell-penetration ability-
Illa, O., Ospina, J., Sánchez-Aparicio, J.-E., Pulido, X., Abengozar, M.Á., Gaztelumendi, N., Carbajo, D., Nogués, C., Rivas, L., Maréchal, J.-D., Royo, M., Ortuño, R.M.
International Journal of Molecular Sciences, 22 (10), art. no. 5092, 2021
- Targeting energy expenditure—drugs for obesity treatment-
Jimenez-Munoz, C.M., López, M., Albericio, F., Makowski, K.
Pharmaceuticals, 14 (5), art. no. 435, .2021
- Refractive index: The ultimate tool for real-time monitoring of solid-phase peptide synthesis. Greening the process-
de la Torre, B.G., Albericio, F., Lopez, J., Ramkisson, S.
Organic Process Research and Development, . 2021
- The Antiproliferative and Apoptotic Effect of a Novel Synthesized S-Triazine Dipeptide Series, and Toxicity Screening in Zebrafish Embryos-
Malebari, A.M., Abd Alhameed, R., Almarhoon, Z., Farooq, M., Wadaan, M.A.M., Sharma, A., de la Torre, B.G., Albericio, F., El-Faham, A.
Molecules (Basel, Switzerland), 26 (4), . 2021
- Application of Quality by Design to the robust preparation of a liposomal GLA formulation by DELOS-susp method-
Merlo-Mas, J., Tomsen-Melero, J., Corchero, J.-L., González-Mira, E., Font, A., Pedersen, J.N., García-Aranda, N., Cristóbal-Lecina, E., Alcaina-Hernando, M., Mendoza, R., Garcia-Fruitós, E., Lizarraga, T., Resch, S., Schimpel, C., Falk, A., Pulido, D., Royo, M., Schwartz, S., Abasolo, I., Pedersen, J.S., Danino, D., Soldevila, A., Veciana, J., Sala, S., Ventosa, N., Córdoba, A.
Journal of Supercritical Fluids, 173, art. no. 105204, .2021
- Propylphosphonic Anhydride (T3P®) as Coupling Reagent for Solid-Phase Peptide Synthesis-
Al Musaimi, O., Wisdom, R., Talbiersky, P., De La Torre, B.G., Albericio, F.
ChemistrySelect, 2021
- Impact of Chemical Composition on the Nanostructure and Biological Activity of α-Galactosidase-Loaded Nanovesicles for Fabry Disease Treatment-
Tomsen-Melero, J., Passemard, S., García-Aranda, N., Díaz-Riascos, Z.V., González-Rioja, R., Nedergaard Pedersen, J., Lyngsø, J., Merlo-Mas, J., Cristóbal-Lecina, E., Corchero, J.L., Pulido, D., Cámara-Sánchez, P., Portnaya, I., Ionita, I., Schwartz, S., Veciana, J., Sala, S., Royo, M., Córdoba, A., Danino, D., Pedersen, J.S., González-Mira, E., Abasolo, I., Ventosa, N.
ACS Applied Materials and Interfaces, . 2021
- 2020 FDA TIDES (peptides and oligonucleotides) harvest-
Musaimi, O.A., Shaer, D.A., Albericio, F., de la Torre, B.G.
Pharmaceuticals, 14 (2), art. no. 145, pp. 1-14. 2021
- s-Triazine: A Privileged Structure for Drug Discovery and Bioconjugation-
Sharma, A., Sheyi, R., de la Torre, B.G., El-Faham, A., Albericio, F.
Molecules (Basel, Switzerland), 26 (4), 2021
- The Pharmaceutical Industry in 2020. An Analysis of FDA Drug Approvals from the Perspective of Molecules-
Torre, B.G., Albericio, F.
Molecules (Basel, Switzerland), 26 (3), 2021
- Structure-Acid Lability Relationship of N-Alkylated α,α-Dialkylglycine Obtained via a Ugi Multicomponent Reaction-
Ramos-Tomillero, I., Sánchez, M.K., Rodríguez, H., Albericio, F.
Molecules (Basel, Switzerland), 26 (1), 2021
- Radical dendrimers based on biocompatible oligoethylene glycol dendrimers as contrast agents for MRI-
Zhang, S., Lloveras, V., Pulido, D., Liko, F., Pinto, L.F., Albericio, F., Royo, M., Vidal-Gancedo, J.
Pharmaceutics, 12 (8), art. no. 772, pp. 1-15. 2020
- Hydroxamate siderophores: Natural occurrence, chemical synthesis, iron binding affinity and use as Trojan horses against pathogens-
Al Shaer, D., Al Musaimi, O., de la Torre, B.G., Albericio, F
European Journal of Medicinal Chemistry, 208, art. no. 112791, 2020
- Insights into the chemistry of the amphibactin–metal (M3+) interaction and its role in antibiotic resistance-
Kaipanchery, V., Sharma, A., Albericio, F., de la Torre, B.G.
Scientific Reports, 10 (1), art. no. 21049, 2020
- Disulfide-Based Protecting Groups for the Cysteine Side Chain-
Chakraborty, A., Sharma, A., Albericio, F., De La Torre, B.G.
Organic Letters, 2020
- Solid-phase synthesis of peptides containing 1-Hydroxypyridine-2-one (1,2-HOPO)-
Al Shaer, D., Albericio, F., de la Torre, B.G.
Tetrahedron Letters, 61 (37), art. no. 152299, 2020,
- Exploiting azido-dichloro-triazine as a linker for regioselective incorporation of peptides through their N, O, S functional groups-
Sharma, A., Kumar, A., El-Faham, A., de la Torre, B.G., Albericio, F.
Bioorganic Chemistry, 104, art. no. 104334, 2020
- Identification of new ocellatin antimicrobial peptides by cdna precursor cloning in the frame of this family of intriguing peptides-
Marani, M.M., Aguilar, S., Cuzziol Boccioni, A.P., Cancelarich, N.L., Basso, N.G., Albericio, F.
Antibiotics, 9 (11), art. no. 751, pp. 1-19. 2020
- Novel 4,6-disubstituted s-triazin-2-yl amino acid derivatives as promising antifungal agents-
Alhameed, R.A., Almarhoon, Z., Sholkamy, E.N., Khan, S.A., Ul-Haq, Z., Sharma, A., De La Torre, B.G., Albericio, F., El-Faham, A.
Journal of Fungi, 6 (4), art. no. 237, pp. 1-15. 2020
- Chiral cyclobutane-containing cell-penetrating peptides as selective vectors for anti-leishmania drug delivery systems-
Illa, O., Olivares, J.-A., Gaztelumendi, N., Martínez-Castro, L., Ospina, J., Abengozar, M.-Á., Sciortino, G., Maréchal, J.-D., Nogués, C., Royo, M., Rivas, L., Ortuño, R.M.
International Journal of Molecular Sciences, 21 (20), art. no. 7502, pp. 1-24, 2020
- OxymaPure Coupling Reagents: Beyond Solid-Phase Peptide Synthesis-
Manne, S.R., De La Torre, B.G., El-Faham, A., Albericio, F.
Synthesis (Germany), 52 (21), pp. 3189-3210, 2020
- Protocol for efficient solid-phase synthesis of peptides containing 1-hydroxypyridine-2-one (1,2-HOPO)-
Al Shaer, D., de la Torre, B.G., Albericio, F.
MethodsX, 7, art. no. 101082, 2020
- The tea-bag protocol for comparison of Fmoc removal reagents in solid-phase peptide synthesis-
Guzmán, F., Gauna, A., Luna, O., Román, T., Álvarez, C., Albericio, F., Cárdenas, C.
Amino Acids, 52 (8), pp. 1201-1205. 2020
- 1,3,5-Triazine as core for the preparation of dendrons-
Sheyi, R., Sharma, A., Kumar, A., El-Faham, A., de la Torre, B.G., Albericio, F.
Arkivoc, 2020 (3), art. no. 245, 2020.
- Competitive ELISA for N-terminal pro-brain natriuretic peptide (NT-proBNP) determination in human plasma-
Colom, G., Salvador, J.-P., Acosta, G., Albericio, F., Royo, M., Marco, M.-P.
The Analyst, 145 (20), pp. 6719-6727. 2020
- N-Butylpyrrolidinone for Solid-Phase Peptide Synthesis is Environmentally Friendlier and Synthetically Better than DMF-
Kumar, A., Alhassan, M., Lopez, J., Albericio, F., de la Torre, B.G.
ChemSusChem, 13 (19), pp. 5288-5294,.2020,
- Barbiturate- and thiobarbituarte-based s-triazine hydrazone derivatives with promising antiproliferative activities-
Al Rasheed, H., Dahlous, K., Sharma, A., Sholkamy, E., El-Faham, A., De La Torre, B.G., Albericio, F.
ACS Omega, 2020
- Revisiting no2 as protecting group of arginine in solid-phase peptide synthesis-
Alhassan, M., Kumar, A., Lopez, J., Albericio, F., de la Torre, B.G.
International Journal of Molecular Sciences, 21 (12), art. no. 4464, pp. 1-12. 2020
- Peptide therapeutics 2.0-
de la Torre, B.G., Albericio, F.
Molecules, 25 (10), art. no. 2293, 2020.
- Breaking a Couple: Disulfide Reducing Agents-
Mthembu, S.N., Sharma, A., Albericio, F., de la Torre, B.G.
ChemBioChem, 2020
- Solid-Phase Synthesis of Head to Side-Chain Tyr-Cyclodepsipeptides Through a Cyclative Cleavage From Fmoc-MeDbz/MeNbz-resins-
Acosta, G.A., Murray, L., Royo, M., de la Torre, B.G., Albericio, F.
Frontiers in Chemistry, 8, art. no. 298, 2020.
- Breaking a Couple: Disulfide Reducing Agents-
Mthembu, S.N., Sharma, A., Albericio, F., de la Torre, B.G.
ChemBioChem, 21 (14), pp. 1947-1954. 2020
- Synthesis of Stable Cholesteryl–Polyethylene Glycol–Peptide Conjugates with Non-Disperse Polyethylene Glycol Lengths-
Cristóbal-Lecina, E., Pulido, D., Martin-Malpartida, P., Macias, M.J., Albericio, F., Royo, M.
ACS Omega, 5 (10), pp. 5508-5519, 2020
- Engineering a Nanostructured Nucleolin-Binding Peptide for Intracellular Drug Delivery in Triple-Negative Breast Cancer Stem Cells-
Pesarrodona, M., Sánchez-García, L., Seras-Franzoso, J., Sánchez-Chardi, A., Baltá-Foix, R., Cámara-Sánchez, P., Gener, P., Jara, J.J., Pulido, D., Serna, N., Schwartz, S., Royo, M., Villaverde, A., Abasolo, I., Vazquez, E.
ACS Applied Materials and Interfaces, .2020
- 2-(Dibenzylamino)butane-1,4-dithiol (DABDT), a Friendly Disulfide-Reducing Reagent Compatible with a Broad Range of Solvents-
Mthembu, S.N., Sharma, A., Albericio, F., De La Torre, B.G.
Organic Letters, 21 (24), pp. 10111-10114. 2019
- Cobalt Amide Imidate Imidazolate Frameworks as Highly Active Oxygen Evolution Model Materials-
Bucci, A., Mondal, S.S., Martin-Diaconescu, V., Shafir, A., Lloret-Fillol, J.
ACS Applied Energy Materials 2019
- Optimized Stepwise Synthesis of the API Liraglutide Using BAL Resin and Pseudoprolines-
Carbajo, D., El-Faham, A., Royo, M., Albericio, F.
ACS Omega, 4 (5), pp. 8674-8680. 2019
- Carbosilane Dendron-Peptide Nanoconjugates as Antimicrobial Agents-
Fernandez, J., Acosta, G., Pulido, D., Malý, M., Copa-Patiño, J.L., Soliveri, J., Royo, M., Gómez, R., Albericio, F., Ortega, P., De La Mata, F.J.
Molecular Pharmaceutics, . 2019
- Pseudo-Wang Handle for the Preparation of Fully Protected Peptides. Synthesis of Liraglutide by Fragment Condensation-
Carbajo, D., Fransen, P., El-Faham, A., Royo, M., Albericio, F
Organic Letters, . 2019 - Environmental effects determine the structure of potential b-amino acid based foldamer-
F. Sussman, V. M. Sánchez-Pedregal, J. C. Estévez, R. Balo, J. Jiménez-Barbero, A. Ardá, A. Gimeno, M. Royo, M. C, Villaverde, R. J. Estévez
Chemistry European Journal (2018), 24, 10625-10629.
- Solid-phase synthesis of homodetic cyclic peptides form Fmoc-MeDbZ-resin-
M. Abdel, A.H. Shimaa, G. A. Acosta, M. Royo, A. El-Faham, B. G. de la Torre, F. Albericio
Tetrahedron Letters (2018), 59, 1779-1782.
- Stimuli-responsive functionalization strategies to spatially and temporally control surface properties: Michael vs Diels-Alder type additions.-
A.R. Kyvik, C. Luque-Corredera, D. Pulido, M. Royo, J. Veciana, J. Guasch, I. Ratera
Journal of Physical Chemistry B (2018), 122, 4481-4490.
- Development of surface modified biodegradable polymeric nanoparticles to deliver GSE24.2 peptide to cells: A promising approach for the treatment of defective telomerase disorders.-
S. P. Egusquiaguirre, C. Manguán-García, L. Pintado-Berninches, L. Iarriccio,D. Carbajo, F. Albericio, M. Royo, J. L. Pedraz, R. M. Hernández, R.Perona, M. Igartua
European Journal of Pharmaceutics and Biopharmaceutics (2015), 91, 91-102
- Facile solid-phase synthesis of head-side chain cyclothiodepsipeptides through a cyclative cleavage from MeDbz-resin-
G. A. Acosta, M. Royo, B. G. de la Torre, F. Albericio
Tetrahedron Letters (2017), 58, 2788-2791.
- Insulin-mimetic compound hexaquis (benzylammonium) decavanadate is antilipolytic in human fat cells-
C. Carpéné, S. Garcia-Vicente, M. Serrano, L. Marti, C. Belles, M. Royo, J. Galitzky, A. Zorzano, X. Testar.
World J. Diabetes (2017), 8, 143-153.
- Highly versatile polyelectrolyte complexes for improving the enzyme replacement therapy of lysosomal storage disorders-
M. Gianotti , I.Abasolo, M.Oliva, F. Andrade, N. García-Aranda, M. Melgarejo, D. Pulido, J.L. Corchero, Y. Fernández, A. Villaverde, M. Royo, M.F. García-Parajo, F. Sanz, S. Schwartz.
ACS Applied Materials & Interfaces (2016), 8, 25741-25752.
- α-Galactosidase A Loaded Nanoliposomes with Enhanced Enzymatic Activity and Intracellular Penetration-
I. Cabrera, I. Abasolo, J. L. Corchero, E. Elizondo, P. Rivera, S. Sala, M. Rivas, M. Melgarejo, D. Pulido, M. Royo, F. Albericio, A. Villaverde, M. F. García-Parajo, S. Schwartz Jr., N. Ventosa, J. Veciana
Advanced Healthcare Materials (2016), 5, 829-840.
- An immunochemical strategy based on peptidoglycan synthetic peptide epitopes to diagnose Staphylococcus aureus infections.-
C.Pastells, G. Acosta, N. Pascual, F. Albericio, M. Royo, M.-P. Marco
Analytica Chimica Acta (2015), 889, 203-211.
- Injectable hyaluronan hydrogels with peptide-binding dendrimers modulate the controlled release of BMP-2 and TGF-b1.-
R. J. Seelbach, P. Fransen, D. Pulido, M. D’Este, F. Duttenhoefer, S. Sauerbier, T. Freiman, P. Niemeyer, F. Albericio, M. Alini, M. Royo, A. Mata, D. Eglin
Macromolecular Bioscience (2015), 15, 1035-1044.
- A solid-phase combinatorial approach for indoloquinolizidinepeptides with high affinity at D1 and D2 dopamine receptors.-
A. Molero, M. Vendrell *, J. Bonaventura, J. Zachmann, L. López, L. Pardo, C. Lluis, Antoni Cortés, F. Albericio, V. Casadó, M. Royo
European Journal of Medicinal Chemistry (2015), 97-173-180.
- r1 and r1 relaxivities of dendrons based on a OEG-DTPA architecture: effect of Gd3+ placement and dendron functionalization-
P. Fransen, D. Pulido, L. Simon-Gracia, A. P. Candiota, C. Arus, F. Albericio, M. Royo*
Journal of Nanotechnology (2015), 1-9
- Gated mesoporous silica nanoparticles using a double-role circular peptide for the controlled and target-preferential release of doxorubicin in CXCR4-expressing lymphoma cells-
C. de la Torre, I. Casanova, G. Acosta, C. Coll, M. J. Moreno, F. Albericio, E. Aznar, R. Mangues*, M. Royo*, F.Sancenón, R. Martínez-Máñez*
Advanced Functional Materials (2015), 25, 687-695.
- Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo-
E.M. Novoa, N. Camacho, A.Tor, B. Wilkinson, S. Moss, P. Marín-García, I. G. Azcárate, J. M. Bautista, A. C. Mirando, C.S. Francklyn, S. Varón, M. Royo, A. Cortés, L. Ribas de Pouplana
Proceedings of National Academy of Sciences USA (2014), 111, E5508-E5517
- Triazene as a powerful tool for solid-phase derivatization of phenylalanine containing peptides: Zygosporamide analogues as a proof of concept-
C. Torres-García, D.Pulido, F. Albericio, M. Royo*, Ernesto Nicolás*
Journal of Organic Chemistry (2014), 79,11409-11415.
- Multivalent dendrimers presenting spatially controlled clusters of binding epitopes in thermoresponsive hyaluronan hydrogels.-
R. J. Seelbach, P. Fransen, M. Peroglio, D. Pulido, P. Lopez-Chicon, F. Duttenhoefer, S. Sauerbier, T. Freiman, P. Niemeyer, C. Semino, F. Albericio, M. Alini, M. Royo, A. Mata, D. Eglin.
Acta Biomaterialia (2014), 10, 4340-4350.
- High control, fast growth OEG-based dendron synthesis via a sequential process of copper free-diazo transfer and click chemistry.-
P. Fransen, D.Pulido, C.Sevrin, C.Granfils, F.Albericio*, M. Royo*
Macromolecules (2014), 47, 2585–2591.
- Amphiphilic cationic carbosilane-PEG dendrimers: synthesis and applications in gene therapy.-
J. Sánchez-Nieves, P. Fransen, D.Pulido, R. Lorente, M. A. Muñoz-Fernández, F.Albericio, M. Royo*, R. Gómez*, F. Javier de la Mata*
European Journal of Medicinal Chemistry (2014), 31, 43-52.
- Controlling multivalency and multimodality: up to pentamodal dendritic platforms based on diethylenetriaminepentaacetic acid Cores.-
D.Pulido, F. Albericio,* M. Royo*
Organic Letters (2014), 16, 1318−1321.
- Sistemas multivalentes para nanomedicina
Coordinator: Miriam Royo Expósito
Grant: RTI2018-093831-B-I00 funded by MCIN/AEI/10.13039/501100011033/ y por FEDER Una manera de hacer Europa
Period: 2019-2022
Funding: 214.600,00
- Smart multifunctional GLA-nanoformulation for Fabry disease (Smart4Fabry)
[av_image src='https://www.iqac.csic.es/wp-content/uploads/2020/07/Miriam-Royo.jpg' attachment='9337' attachment_size='full' align='left' styling='' hover='' link='' target='' caption='' font_size='' appearance='' overlay_opacity='0.4' overlay_color='#000000' overlay_text_color='#ffffff' copyright='' animation='no-animation' av_uid='' custom_class='' admin_preview_bg=''][/av_image]
Funding entity: European Community Horizon 2020, NMBP-2016-2STAGE-HEALTH (nºagreement: 720942-2)
Coordinator: Nora Ventosa
Period: 2017-2020 - Targeted Quatsome nanocarriers for the delivery of microRNA for neuroblastoma therapy (TAG-SMARTLY)
Funding entity: CIBER BBN. Proyectos de valorización 2020 de CIBER BBN
Coordinator: Nora Ventosa Principal investigator partner 2: Miriam Royo
Period: 2020-2021 - Red en Péptidos, en Biomedicina y Nanociencia (BIONAPEP)
Funding entity: Ministerio de Ciencia, Innovación y Universidades, MICINN (RED2018-102417-T)
Coordinator: Eugenio Vázquez
Period: 2020-2021 - ACE-2 derived peptide super-binders with enhanced efficacy for the inhibition of SARS-COV-2 infection (ADVISOR)
Funding entity: Fondo Supera COVID19 Santander-CRUE
Coordinator: Jacinto López-Sagaseta Principal investigators partner 3: Miriam Royo and Daniel Pulido
Period: 01/09/2020-31/08/2021 - Point of care for the rapid detection of SARS-CoV-2 (POC4COV)
Funding entity: Agencia Estatal Consejo Superior de Investigaciones Científicas (CSIC-COV19-041)
Coordinators: César Fernández y Pilar Marco
Period: 01/04/2020-31/03/2021 - Multivalent systems for Nanomedicine (MS4N)
Funding entity: Ministerio de Ciencia, Innovación y Universidades, MICINN (RTI2018-093831-B-I00)
Principal investigator: Miriam Royo
Period: 2019-2022
