QUÍMICA FÍSICA DE SISTEMAS TENSIOACTIVOS
Jefe de grupo: Ramon Pons
El tema general de la investigación es la química-física de tensioactivos y de sistemas basados en tensioactivo. Se presta especial atención a la dinámica de las transformaciones (emulsificación y solubilización) y al comportamiento de nuevo tensioactivos biocompatibles. Las principales técnicas son SAXS-WAXS, dispersión de luz, tensiometria, conductividad y electrodo selectivo.
Procesos de no equilibrio en sistemas tensioactivos
Diversas técnicas aplicadas a la medición de la evolución de la estructura de sistemas tensioactivos. Por ejemplo, emulsificación, solubilización y reconstitución de vesículas.
Computacional
Modelado de estructuras formadas por tensioactivo tales como micelas y cristales líquidos y computación de curvas de dispersión y difracción de rayos-x de ángulo pequeño.
Instrumental
Técnicas Instrumentales al alcance del grupo que podemo aplicar a la caracterización de la estructura de sistemas en el rango del milímetro hasta subnanométrico:
- Dispersión de rayos- X, SAXS-WAXS
- Dispersión de luz láser (DLS, QELS y potencial-Z)
- Microscopia Óptica
- Conductividad
- Electrodo Selectivo
- Tensiometría (gota colganteyi placa de Wilhelmy)
- Balanza de Langmuir
- Reología
Personal científico
Ramon Pons
Investigador Científico
ramon.pons@iqac.csic.es
Listado completo de publicaciones
Personal de laboratorio
Jaume Caelles
Técnico Superior
jaume.caelles@iqac.csic.es
- Formulating a Horseradish Extract in Phospholipid Vesicles to Target the Skin-
Maria De Luca,Luca Casula,Carlo Ignazio Giovanni Tuberoso,Ramon Pons,Maria del Carmen Morán,María Teresa García,Giuseppe Martelli,Antonio Vassallo and Carla Caddeo
Pharmaceutics 2024, 16(12), 1507
- In vivo antihyperglycemic effect of Ptilostemon casabonae (L.) Greuter leaf extract and its liposomal formulation-
Simone Pani , Carla Caddeo , Laura Dazzi , Giuseppe Talani , Enrico Sanna , Arianna Marengo , Patrizia Rubiolo , Ramon Pons , Aurélien Dupont , Sonia Floris , Cinzia Sanna , Francesca Pintus
Journal of Drug Delivery Science and Technology, Volume 100, 106078, 2024 - Antimicrobial and Anesthetic Niosomal Formulations Based on Amino Acid-Derived Surfactants-
Martina Romeo, Zakaria Hafidi , Rita Muzzalupo , Ramon Pons, María Teresa García, Elisabetta Mazzotta and Lourdes Pérez
Molecules 2024, 29, 2843. https://doi.org/10.3390/molecules29122843 - A Nano-Based Approach to Deliver Satureja thymbra Essential Oil to the Skin: Formulation and Characterization-
Pani, S., Caddeo, C., Sanna, C., Pintus, F., Floris, S., Pons, R., Dupont, A., Tuberoso, C.I.G.
Molecules, 29 (5), art. no. 1041, 2024.
- Tailored Design of a Water-Based Nanoreactor Technology for Producing Processable Sub-40 Nm 3D COF Nanoparticles at Atmospheric Conditions-
Llauradó-Capdevila, G., Veciana, A., Guarducci, M.A., Mayoral, A., Pons, R., Hertle, L., Ye, H., Mao, M., Sevim, S., Rodríguez-San-Miguel, D., Sorrenti, A., Jang, B., Wang, Z., Chen, X.-Z., Nelson, B.J., Matheu, R., Franco, C., Pané, S., Puigmartí-Luis, J.
Advanced Materials, 36 (14), art. no. 2306345, 2024
- Tackling the challenges of the oral administration of a fermented flour extract with liposomes: Effect on intestinal HT-29 cells-
Tomassi, E., Lucchesi, D., Caddeo, C., Valenti, D., Sancho, V., Pons, R., Pucci, L.
Food Bioscience, 56, art. no. 103215, 2023.
- Microstructural and Viscoelastic Properties of Liquid Crystal Phases of Soybean Lecithin with Olive and Castor Oils at Low Water Contents-
Godoy, C.A., Valiente, M., Muñoz, W., Bonilla, P., Pons, R., Montalvo, G.
Journal of Chemical and Engineering Data, 68 (7), pp. 1534-1542. 2023
- Phenylalanine and Tryptophan-Based Surfactants as New Antibacterial Agents: Characterization, Self-Aggregation Properties, and DPPC/Surfactants Vesicles Formulation-
Hafidi, Z., Pérez, L., El Achouri, M., Pons, R.
Pharmaceutics, 15 (7), art. no. 1856, 2023.
- Ceratonia siliqua L. Pod Extract: From Phytochemical Characterization to Liposomal Formulation and Evaluation of Behaviour in Cells-
De Luca, M., Tuberoso, C.I.G., Pons, R., García, M.T., Morán, M.D.C., Martelli, G., Vassallo, A., Caddeo, C.
Antioxidants, 12 (6), art. no. 1209, 2023.
- Phenolic Fingerprint, Bioactivity and Nanoformulation of Prunus spinosa L. Fruit Extract for Skin Delivery-
De Luca, M., Tuberoso, C.I.G., Pons, R., García, M.T., Morán, M.D.C., Ferino, G., Vassallo, A., Martelli, G., Caddeo, C.
Pharmaceutics, 15 (4), art. no. 1063, 2023
- High Performance Computing PP-Distance Algorithms to Generate X-ray Spectra from 3D Models-
Int. J. Mol. Sci. 2022, 23, 11408.
González, C.; Balocco, S.; Bosch, J.; de Haro, J.M.; Paolini, M.; Filgueras, A.; Álvarez, C.; Pons, R.
- Green cationic arginine surfactants: Influence of the polar head cationic character on the self-aggregation and biological properties-
Pérez, L., Pons, R., Oliveira de Sousa, F.F., Morán, M.D.C., Ramos da Silva, A., Pinazo, A
Journal of Molecular Liquids, 339, art. no. 116819, . 2021
- Mwnts or peg as stability enhancers for dna–cationic surfactant gel particles-
Mezei, A., Pons, R.
International Journal of Molecular Sciences, 22 (16), art. no. 8801, 2021
- Monitoring the formation of a colloidal lipid gel at the nanoscale: vesicle aggregation driven by a temperature-induced mechanism-
Kirian Talló, Ramon Pons, César González and Olga López
J. Mater. Chem. B, 2021, Advance Article
- Peptide Amphiphilic-Based Supramolecular Structures with Anti-HIV-1 Activity-
Maria J. Gómara, Ramon Pons, Carolina Herrera, Paul Ziprin, and Isabel Haro
Bioconjugate Chem. 32 (9), pp. 1999-2013. 2021
- Gels formed from the interaction of lipid vesicles: Influence of charge in their structural and rheological properties-
Talló, K., Vílchez, S., Pons, R., López, O.
Journal of Molecular Liquids, 322, art. no. 114957,2021
- Aggregation behavior, antibacterial activity and biocompatibility of catanionic assemblies based on amino acid‐derived surfactants-
Pérez, L., Pinazo, A., Morán, M.C., Pons, R.
International Journal of Molecular Sciences, 21 (23), art. no. 8912, pp. 1-23. 2020
- Biocompatible catanionic vesicles from arginine-based surfactants: A new strategy to tune the antimicrobial activity and cytotoxicity of vesicular systems-
Pinazo, A., Pons, R., Marqués, A., Farfan, M., da Silva, A., Perez, L.
Pharmaceutics, 12 (9), art. no. 857, pp. 1-24. 2020
- A new automated system for the preparation of sclerosant foam: A study of the physical characteristics produced and the device settings required-
Roche, E., Pons, R., Roche, O., Puig, A.
Phlebology, 35 (9), pp. 724-733, 2020
- Pathway selection as a tool for crystal defect engineering: A case study with a functional coordination polymer-
Afshin Abrishamkar, Salvio Suárez–García, Semih Sevim, Alessandro Sorrenti, Ramon Pons, Shi-Xia Liu, Silvio Decurtins, Guillem Aromí , David Aguilà, Salvador Pané, Andrew J. deMelloa , Aurelian Rotaru, Daniel Ruiz–Molina, Josep Puigmartí-Luis
Applied Materials Today.20, 100636, Sep 2020
- Biomimetic Synthesis of Sub-20 nm Covalent Organic Frameworks in Water-
Carlos Franc, David Rodríguez-San-Miguel, Alessandro Sorrenti, Semih Sevim, Ramon Pons, Ana E. Platero-Prats, Marko PavlovicIs, tvan Szilágyi, M. Luisa Ruiz Gonzalez, José M. González-Calbet, Davide Bochicchio, Luca Pesce, Giovanni M. Pavan, Inhar Imaz, Mary Cano-Sarabia, Daniel Maspoch, Salvador Pané, Andrew J. de Mello, Felix Zamora, Josep Puigmartí-Luis
J. Am. Chem. Soc. 2020, 142, 7, 3540-3547
- Chiral pH-sensitive cyclobutane β-amino acid-based cationic amphiphiles: Possible candidates for use in gene therapy-
Pi-Boleda, B., Bouzas, M., Gaztelumendi, N., Illa, O., Nogués, C., Branchadell, V., Pons, R., Ortuño, R.M.
Journal of Molecular Liquids, 297, 1 January 2020, 111856
- Preparation and characterization of a supramolecular hydrogel made of phospholipids and oleic acid with a high water content-
Talló, K., Bosch, M., Pons, R., Cocera, M., López, O.
J. Mater. Chem. B, 2020,8, 161-167
- Gemini histidine based surfactants: Characterization; surface properties and biological activity-
Pinazo, A., Pons, R., Bustelo, M., Manresa, M.Á., Morán, C., Raluy, M., Pérez, L.
Journal of Molecular Liquids, 289, art. no. 111156, 2019
- Cyclobutane Scaffold in Bolaamphiphiles: Effect of Diastereoisomerism and Regiochemistry on Their Surface Activity Aggregate Structure-
Bernat Pi-Boleda, Alessandro Sorrenti, Marta Sans, Ona Illa , Ramon Pons , Vicenç Branchadell , and Rosa M. Ortuño
Langmuir, 2018, 34 (38), pp 11424–11432
- Stability, biocompatibility and antioxidant activity of PEG-modified liposomes containing resveratrol-
Caddeo, C., Pucci, L., Gabriele, M., Carbone, C., Fernàndez-Busquets, X., Valenti, D., Pons, R., Vassallo, A., Fadda, A.M., Manconi, M.
Int J Pharm. 2018, 538 (1-2), 40-47.
- Nutriosomes: Prebiotic delivery systems combining phospholipids, a soluble dextrin and curcumin to counteract intestinal oxidative stress and inflammation-
Catalán-Latorre, A., Pleguezuelos-Villa, M., Castangia, I., Manca, M.L., Caddeo, C., Nácher, A., Díez-Sales, O., Peris, J.E., Pons, R., Escribano-Ferrer, E., Fadda, A.M., Manconi, M.
Nanoscale 2018, 10 (4), 1957-1969.
- Transfection of antisense oligonucleotides mediated by cationic vesicles based on non-ionic surfactant and polycations bearing quaternary ammonium moieties-
Mayr, J., Grijalvo, S., Bachl, J., Pons, R., Eritja, R., Díaz, D.D.
Int J Mol Sci., (2017) 18 (6), art. no. 1139 .
- Physico-chemical characterization of succinyl chitosan-stabilized liposomes for the oral co-delivery of quercetin and resveratrol-
Caddeo, C., Pons, R., Carbone, C., Fernàndez-Busquets, X., Cardia, M.C., Maccioni, A.M., Fadda, A.M., Manconi, M.
Carbohydr Polym. (2017), 157, pp. 1853-1861.
- Chiral Cyclobutane β-Amino Acid-Based Amphiphiles: Influence of Cis/Trans Stereochemistry on Condensed Phase and Monolayer Structure-
Sorrenti, A., Illa, O., Ortuño, R.M., Pons, R.
Langmuir (2016), 32 (27), pp. 6977-6984.
- Santosomes as natural and efficient carriers for the improvement of phycocyanin reepithelising ability in vitro and in vivo-
Castangia, I., Manca, M.L., Caddeo, C., Bacchetta, G., Pons, R., Demurtas, D., Diez-Sales, O., Fadda, A.M., Manconi, M.
Eur J Pharm Biopharm (2016), 103, pp. 149-158.
- New cationic vesicles prepared with double chain surfactants from arginine: Role of the hydrophobic group on the antimicrobial activity and cytotoxicity-
Pinazo, A., Petrizelli, V., Bustelo, M., Pons, R., Vinardell, M.P., Mitjans, M., Manresa, A., Perez, L.
Colloids Surf B: Biointerfaces (2016), 141, pp. 19-27.
- Supramolecular Arrangement of Molybdenum Carbonyl Metallosurfactants with CO-Releasing Properties-
Parera, E., Marín-García, M., Pons, R., Comelles, F., Suades, J., Barnadas-Rodríguez, R.
Organometallics (2016), 35 (4), pp. 484-493.
- Catanionic vesicles and DNA complexes: A strategy towards novel gene delivery systems-
Pucci, C., Scipioni, A., Diociaiuti, M., La Mesa, C., Pérez, L., Pons, R.
RSC Advances (2015), 5 (99), pp. 81168-81175.
- Chiral Cyclobutane β-Amino Acid-Based Amphiphiles: Influence of Cis/Trans Stereochemistry on Solution Self-Aggregation and Recognition-
Sorrenti, A., Illa, O., Pons, R., Ortuño, R.M.
Langmuir (2015), 31 (35), pp. 9608-9618.
- Characterization and stability of catanionic vesicles formed by pseudo-tetraalkyl surfactant mixtures-
Pucci, C., Pérez, L., La Mesa, C., Pons, R.
Soft Matter (2014), 10 (48), pp. 9657-9667.
- Release of DNA and surfactant from gel particles: The receptor solution effect and the dehydration-hydration aspects-
Mezei, A., Pons, R.
Colloids Surf B: Biointerfaces (2014), 123, pp. 279-285.
- Gemini surfactants from natural amino acids-
Pérez, L., Pinazo, A., Pons, R., Infante, M.
Adv Colloid Interface Sci. (2014), 205, pp. 134-155.
- Complex rhamnolipid mixture characterization and its influence on DPPC bilayer organization-
Haba, E., Pinazo, A., Pons, R., Pérez, L., Manresa, A.
Biochimica et Biophysica Acta – Biomembranes (2014), 1838 (3), pp. 776-783.
- Atomic Model and Micelle Dynamics of QS-21 Saponin-
Pedebos, C.; Pol-Fachin, L.; Pons, R.; Teixeira, C.V.; Teixeira, H.
Molecules; vol: 19 ; Páginas: 3744 - 3760
- The nanostructure of surfactant-DNA complexes with different arrangements-
Mezei, A., Pons, R., Morán, M.C.
Colloids Surf B: Biointerfaces (2013), 111, pp. 663-671.
- Self assembly of pH-sensitive cationic lysine based surfactants-
Mezei, A., Pérez, L., Pinazo, A., Comelles, F., Infante, M.R., Pons, R.
Langmuir (2012), 28 (49), pp. 16761-16771.
- Surface activity and aggregation of pristine and hydrophobically modified inulin-
Morros, J., Infante, M.R., Pons, R.
Soft Matter (2012), 8 (44), pp. 11353-11362.
- Novel biocompatible DNA gel particles-
Morán, M.C., Infante, M.R., Miguel, M.G., Lindman, B., Pons, R.
Langmuir (2010), 26 (13), pp. 10606-10613.
- Headgroup effects on the unusual lamellar-lamellar coexistence and vesicle-to-micelle transition of salt-free catanionic amphiphiles-
Silvas, B.F.B., Marques, E.F., Olsson, U., Pons, R.
Langmuir (2010), 26 (5), pp. 3058-3066.
- Dynamic properties of cationic diacyl-glycerol-arginine-based surfactant/phospholipid mixtures at the air/water interface-
Lozano, N., Pinazo, A., Pérez, L., Pons, R.
Langmuir (2010), 26 (4), pp. 2559-2566.
- Adsorption of polyphenols in wastewater by organo-bentonites-
A.Marsal, E. Bautista, I. Ribosa, R. Pons, M.T. García
Applied Clay Science 44 (2009) 151 – 155
