QUÍMICA COLOIDAL E INTERFACIAL
Jefe de grupo: Carlos Rodríguez
MISIÓN
Comprender y controlar los fenómenos coloidales utilizando estrategias químicas singulares para el diseño y desarrollo de aplicaciones tecnológicas.
VISIÓN
Consolidar la innovación en química coloidal para resolver desafíos tecnológicos y sociales específicos
Nuestro grupo se centra en el autoensamblaje molecular de la materia blanda como vehículo para la fabricación «bottom-up» de nanomateriales, con uso mínimo de energía. Estamos interesados en sistemas nanoestructurados tales como tensioactivos, polímeros, micelas, geles, cristales líquidos, espumas, microemulsiones y nanoemulsiones, que pueden tener aplicaciones directas o usarse como plantillas, directores de estructura o nanoreactores para la síntesis de nanopartículas, nanocompuestos o sólidos nanoporosos. A través de técnicas de última generación intentamos comprender mecanismos fundamentales de agregación, fuerzas coloidales e interacciones interfaciales y su impacto en el tamaño del material, la estructura, la estabilidad y otras propiedades. Utilizamos información molecular y parámetros fisicoquímicos para predecir, controlar y programar la autoorganización jerárquica a múltiples escalas y con creciente complejidad, para materiales con propiedades y aplicaciones novedosas o mejoradas.
web del grupo: http://www.iqac.csic.es/qci/
Nuestra investigación se centra en las siguientes líneas:
- Desarrollo de formulaciones hechas a medida para aplicaciones novedosas basadas en el autoensamblaje de moléculas de tentioactivos, polímeros y otros sistemas coloidales
- Sistemas autoensamblados y dispersiones coloidales como plantillas o agentes directores de estructura en la preparación de materiales funcionales avanzados.
- Design and synthesis of molecular delivery systems towards applications in therapy.
Personal científico
Carlos Federico Rodríguez
Investigador Científico
carlos.rodriguez@iqac.csic.es
Personal de laboratorio
Gabriela Calderó
Lector visitante UB
gabriela.caldero@iqac.csic.es
Santiago Grijalvo
Investigador CIBER
santiago.grijalvo@iqac.csic.es
Adrià Pérez Calm
Investigador contratado
adria.perez@iqac.csic.es
José Antonio Durán González
Técnico de Laboratorio
joseantonio.duran@iqac.csic.es
Víctor Espinosa
Estudiante de grado
victor.espinosa@iqac.csic.es
Mateo Pava
Estudiante de intercambio
mateo.pava@iqac.csic.es
- Effects of a nanoemulsion with Copaifera officinalis oleoresin against monogenean parasites of Colossoma macropomum: A Neotropical Serrasalmidae-
Valentim, D.S.S., Duarte, J.L., Oliveira, A.E.M.F.M., Cruz, R.A.S., Carvalho, J.C.T., Solans, C., Fernandes, C.P., Tavares-Dias, M.
J Fish Diseases (2018), 41 (7), pp. 1041-1048.
- Hyaluronan based materials with catanionic sugar-derivedsurfactants as drug delivery systems.-
Roig, M. Blanzat, C. Solans, J. Esquena, M.J. García-Celma
Colloids Surf B: Biointerfaces 2018, 164, 218–223.
- Effect of surface chemistry and associated protein corona on the long-term biodegradation of iron oxide nanoparticles in vivo.-
Stepien, M. Moros, M. Perez-Hernandez, M. Monge, L .Gutiérrez, R.M.M. Fratila, M. Las Heras, S. Menao Guillen, J.J. Puente Lanzarote, C. Solans, J. Pardo, J.M. De La Fuente
ACS Appl Mater Interfaces 2018, 10, 4548−4560.
- Rivas Novel synthetic routes of large-pore magnetic mesoporous nanocomposites (SBA-15/Fe3O4) as potential multifunctional theranostic nanodevices.-
Z.Vargas-Osorio, M.A. Gonzáles-Gómez, Y. Piñeiro, C. Vázquez-Vázquez, C. Rodríguez-Abreu, M.A. López-Quintela, J.
J Mater Chem. B, 2017, 5, 9395-9404.
- Design of parenteral MNP-loaded PLGA nanoparticles by a low-energy emulsification approach as theragnostic platforms for intravenous or intratumoral administration.-
Calderó, C. Fornaguera, L. Zadoina, A. Dols-Perez, C. Solans.
Colloids Surf B: Biointerfaces 2017, 160 ,535–542.
- Adsorption of Marine Phycotoxin Okadaic Acid on a Covalent Organic Framework.-
M. Salonen, S. R. Pinela, S. P.S. Fernandes, J. Loucano, E. Carbo-Argibay, M. P. Sarria, C. Rodrıguez-Abreu, J. Peixoto, B. Espiña.
J Chromatogr A. 2017, 2017,1525, 17–22.
- Emulsion-based Gels with Thermally Switchable Transparency.-
K.Aramaki, K.Masuda, R.Horie, C.Rodríguez-Abreu.
Colloids and Surfaces A: Physicochem Engineer Aspects 2017, 533, 302-307.
- Green synthesis of silver nanoparticles in oil-in-water microemulsion and nano-emulsion using geranium leaf aqueous extract as a reducing agent.-
Rivera-Rangel, R.D., González-Muñoz, M.P., Avila-Rodriguez, M., Razo-Lazcano, T.A., Solans, C.
Colloids Surf A: Physicochem Engin Aspects 2018, 536, 60-67.
- Influence of crosslinked alginate on drug release from highly concentrated emulsions.-
Bonilla, P., Arias, E.M., Solans, C., García-Celma, M.J.
Colloids Surfs A: PhysicocheEngin Aspects 2018, 536, pp. 148-155.
- A colloidally stable water dispersion of Ni nanowires as efficient T2-MRI contrast agent.-
M.Banobre Lopez, C.Bran, C. Rodriguez-Abreu, J. Gallo, M.Vazquez, J. Rivas.
J Mater Chem B, 2017, 5, 3338--3347.
- Versatile Methodology to Encapsulate Gold Nanoparticles in PLGA Nanoparticles Obtained by Nano-Emulsion Templating.-
Fornaguera, N. Feiner-Gracia, A. Dols-Perez, M. J. García-Celma, C. Solans.
Pharmaceutical Research 2017, 34, 1093-1103
- PLGA nanoparticles from nano-emulsion templating as imaging agents: Versatile technology to obtain nanoparticles loaded with fluorescent dyes.-
Fornaguera, N. Feiner-Gracia., G. Calderó, M.J.Garcia-Celma, C. Solans
Colloids Surf B: Biointerfaces 2016, 147, 201 - 209.
- From Chromonic Self-Assembly to Hollow Carbon Nanofibers: Efficient Materials in Supercapacitor and Vapor-Sensing Applications.-
J.R. Magana, Y.V. Kolen'ko, F.L. Deepak, C. Solans, R.G. Shrestha, J.P. Hill, K. Ariga, L.K. Shrestha, C. Rodriguez-Abreu .
ACS Appl Mater Interfaces 2016, 8, 31231–31238.
- Self-Assembly and Formation of Chromonic Liquid Crystals from the Dyes Quinaldine Red Acetate and Pyronin Y.-
R. Magana, M. Homs, C. Solans, M. Obiols-Rabasa, L. M. Salonen, C. Rodríguez-Abreu.
J Phys Chem B 2016, 120, 250–258.
- PLGA nanoparticles prepared by nano-emulsion templating using low-energy methods as efficient nanocarriers for drug delivery across the blood–brain barrier.-
Fornaguera, A. Dols-Perez, G. Calderó, M.J. García-Celma, J. Camarasa, C. Solans.
J Controlled Release. 2015, 211, 134-143.
- Interactions of PLGA nanoparticles with blood components: protein adsorption, coagulation, activation of the complement system and hemolysis studies.-
Fornaguera, G.Calderó, M.Mitjans, M. P. Vinardell, C. Solans, C. Vauthier.
Nanoscale 2015, 7, 6045-6058.
- Chromonic self-assemblies in a series of dialkyl-thiacarbocyanine dyes and generalization of a facile route for the synthesis of fluorescent nanostructured silica fibers-
Magana, J.R., Solans, C., Salonen, L.M., Carbó-Argibay, E., Gallo, J., Tiddy, G.J.T., Rodríguez-Abreu, C.
J Taiwan Inst Chem Engin, 92, 134-142, 2018.
- Editorial for Special issue on Formula VIII-
Durand, A., Faers, M., Rodríguez-Abreu, C.
Colloids Surf A: Physicochem Engin Aspects, 2018, 536, pp. 1-2.
- NLCs as a potential carrier system for transdermal delivery of forskolin-
Lason, E., Sikora, E., Miastkowska, M., Escribano, E., Garcia-Celma, M.J., Solans, C., Llinas, M., Ogonowski, J.
Acta Biochimica Polonica, 65 (3), pp. 437-442. 2018
- Low-energy nano-emulsification approach as a simple strategy to prepare positively charged ethylcellulose nanoparticles-
Leitner, S., Solans, C., García-Celma, M.J., Calderó, G.
Carbohydrate Polymers, 205, pp. 117-124. 2019
- Analytical Methods to Characterize and Purify Polymeric Nanoparticles-
Fornaguera, C., Solans, C.
International Journal of Polymer Science, 2018, art. no. 6387826, 2018
- Electrical Impedance Spectroscopy Microflow Cytometer for Cell Viability Tests-
González-Murillo, J.J., Monge-Azemar, M., Bartoli, J., Flores, A., Moreno, M., García-Celma, M., Romano-Rodríguez, A., Svendsen, W., Samitier, J., Rodríguez-Trujillo, R.
Proceedings of the 2018 12th Spanish Conference on Electron Devices, CDE 2018, art. no. 8597037, 2018
- Formation of Nanoemulsion Containing Ibuprofen by PIC Method for Topical Delivery-
Salim, N., Jose García-Celma, M., Escribano, E., Nolla, J., Llinàs, M., Basri, M., Solans, C., Esquena, J., Tadros, T.F.
Materials Today: Proceedings, 5, pp. S172-S179. 2018
- Simultaneous extraction and obtention of a novel nano-dispersion from Mikania glomerata Spreng: Monitoring coumarin content and increasing the biological and industrial potential of a classical cultivated herb-
Santana, E.A., Rodrigues, R.F., de Almeida, F.B., Oliveira, A.E.M.D.F.M., Cruz, R.A.S., França, H.S., Batitucci, M.D.C.P., Dutra, J.C.V., da Silva Ferreira, P., Amado, J.R.R., Carvalho, J.C.T., Kelmann, R.G., Solans, C., Fernandes, C.P.
Industrial Crops and Products, 135, pp. 49-56.2019
- Food-grade Pickering stabilizers obtained from a protein-rich lupin cultivar (AluProt-CGNA®): Chemical characterization and emulsifying properties-
Burgos-Díaz, C., Wandersleben, T., Olivos, M., Lichtin, N., Bustamante, M., Solans, C.
Food Hydrocolloids, 87, pp. 847-857. 2019
- Formulating stable hexosome dispersions with a technical grade diglycerol-based surfactant-
Magana, J.R., Homs, M., Esquena, J., Freilich, I., Kesselman, E., Danino, D., Rodríguez-Abreu, C., Solans, C.
Journal of Colloid and Interface Science, 550, pp. 73-80. 2019
- Modulating size and surface charge of ethylcellulose nanoparticles through the use of cationic nano-emulsion templates-
Calderó, G., Leitner, S., García-Celma, M.J., Solans, C.
Carbohydrate Polymers, 225, art. no. 115201, 2019
- 32nd Conference of the European Colloid and Interface Society, 2–7 September 2018 in Ljubljana, Slovenia-
Bešter-Rogač, M., Kroflič, A., Rodríguez-Abreu, C.
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 580, art. no. 123849,2019
- Cubic liquid crystalline structures in diluted, concentrated and highly concentrated emulsions for topical application: Influence on drug release and human skin permeation-
Arias, E.M., Guiró, P., Rodriguez-Abreu, C., Solans, C., Escribano-Ferrer, E., García-Celma, M.J.
International Journal of Pharmaceutics, 569, art. no. 118531, 2019
- Template-directed self-organization of colloidal PbTe nanocrystals into pillars, conformal coatings, and self-supported membranes-
Piotrowski, M., Borme, J., Carbó-Argibay, E., Sharma, D., Nicoara, N., Sadewasser, S., Petrovykh, D.Y., Rodríguez-Abreu, C., Kolen'Ko, Y.V.
Nanoscale Advances, 1 (8), pp. 3049-3055. 2019
- PLGA cationic nanoparticles, obtained from nano-emulsion templating, as potential DNA vaccines-
Soler Besumbes, E., Fornaguera, C., Monge, M., García-Celma, M.J., Carrión, J., Solans, C., Dols-Perez, A.
European Polymer Journal, 120, art. no. 109229, 2019, .
- Simple Method for Rheological Determination of Surfactant Layer Thickness, Adsorbed on Soft Rubber Particles-
Singh, M., Tadros, T.F., Solans, C., Booten, K., Levecke, B., Esquena, J.
Langmuir, 2019
- Biomedical perfluorohexane-loaded nanocapsules prepared by low-energy emulsification and selective solvent diffusion-
Calderó, G., Rodríguez-Abreu, C., González, A., Monge, M., García-Celma, M.J., Solans, C.
Materials Science and Engineering C, 111, art. no. 110838, 2020
- Key features of nano-emulsion formation by the phase inversion temperature method-
Feng, J., Esquena, J., Rodriguez-Abreu, C., Solans, C.
Journal of Dispersion Science and Technology, .2020
- A Concise Review on Nano‐emulsion Formation by the Phase Inversion Composition (PIC) Method-
Feng, J., Rodríguez-Abreu, C., Esquena, J., Solans, C.
Journal of Surfactants and Detergents, 2020
- Short and ultrashort antimicrobial peptides anchored onto soft commercial contact lenses inhibit bacterial adhesion-
Salvagni, E., García, C., Manresa, À., Müller-Sánchez, C., Reina, M., Rodríguez-Abreu, C., García-Celma, M.J., Esquena, J.
Colloids and Surfaces B: Biointerfaces, 196, art. no. 111283, 2020
- Ultrasound/radiation-responsive emulsions-
Calderó, G., Paradossi, G.
Current Opinion in Colloid and Interface Science, 49, pp. 118-132. 2020
- 1D materials from ionic self-assembly in mixtures containing chromonic liquid crystal mesogens-
Rodríguez-Abreu, C., Kolen'ko, Y.V., Kovnir, K., Sanchez-Dominguez, M., Shrestha, R.G., Bairi, P., Ariga, K., Shrestha, L.K.
Physical Chemistry Chemical Physics, 22 (40), pp. 23276-23285. 2020
- PEGylated perylene bisimides: Chromonic building blocks for the aqueous synthesis of nanostructured silica materials-
Pérez-Calm, A., Esquena, J., Salonen, L.M., Rodríguez-Abreu, C.
Journal of Molecular Liquids, 325, art. no. 114657, 2021.
- Ethylcellulose nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms-
Leitner, S., Solans, C., García-Celma, M.J., Morral-Ruíz, G., Melgar-Lesmes, P., Calderó, G.
Materials Science and Engineering C, art. no. 111682, 2020
- Preparation of non-toxic nano-emulsions based on a classical and promising Brazilian plant species through a low-energy concept-
Ortiz-Zamora, L., Bezerra, D.C., de Oliveira, H.N.S., Duarte, J.L., Guisado-Bourzac, F., Chil-Núñez, I., da Conceição, E.C., Barroso, A., Mourão, R.H.V., de Faria Mota Oliveira, A.E.M., Cruz, R.A.S., Carvalho, J.C.T., Solans, C., Fernandes, C.P.
Industrial Crops and Products, 158, art. no. 112989, 2020
- Epitopes for Multivalent Vaccines Against Listeria, Mycobacterium and Streptococcus spp: A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase-
Alvarez-Dominguez, C., Salcines-Cuevas, D., Teran-Navarro, H., Calderon-Gonzalez, R., Tobes, R., Garcia, I., Grijalvo, S., Paradela, A., Seoane, A., Sangari, F.J., Fresno, M., Calvo-Montes, J., Pérez Del Molino Bernal, I.C., Yañez-Diaz, S.
Frontiers in Cellular and Infection Microbiology, 10, art. no. 573348, . 2020
- Screening of extra virgin olive oil-in-bitter orange juice (O/W) nano-emulsions stabilized with different food-grade surfactants: A model system for natural daily use salad dressing-
Yalçinöz, Ş., Erçelebi, E., Solans, C., Tadros, T.
Italian Journal of Food Science, 32 (4), pp. 873-892. 2020
- Ethylcellulose nanoparticles prepared from nano-emulsion templates as new folate binding haemocompatible platforms-
Leitner, S., Solans, C., García-Celma, M.J., Morral-Ruíz, G., Melgar-Lesmes, P., Calderó, G.
Materials Science and Engineering C, 120, art. no. 111682, 2021
- Mechanochemical Synthesis of TiO2 Nanoparticles and Their Self-organization at Interfaces to Produce Emulsion-Templated Photocatalytic Porous Polymers-
Vílchez, A., Rodriguez-Abreu, C., Esquena, J., Botta, P.M.
Journal of Inorganic and Organometallic Polymers and Materials, 2021
- Graphene-based hybrid materials as promising scaffolds for peripheral nerve regeneration-
Grijalvo, S., Díaz, D.D.
Neurochemistry International, 147 art. no. 105005, 2021
- A nanocellulose-based platform towards targeted chemo-photodynamic/photothermal cancer therapy-
Do, T.T.A., Grijalvo, S., Imae, T., Garcia-Celma, M.J., Rodríguez-Abreu, C.
Carbohydrate Polymers, 270, art. no. 118366, 2021
- Xanthan-Fe3O4Nanoparticle Composite Hydrogels for Non-Invasive Magnetic Resonance Imaging and Magnetically Assisted Drug Delivery-
Ribeiro, M., Boudoukhani, M., Belmonte-Reche, E., Genicio, N., Sillankorva, S., Gallo, J., Rodríguez-Abreu, C., Moulai-Mostefa, N., Bañobre-López, M.
ACS Applied Nano Materials, 4 (8), pp. 7712-7729. 2021
- Deconstruction of technical grade diglycerol isostearate enables the controlled preparation of hexosomes and liposomes-
Magana, J.R., Esquena, J., Solans, C., Rodriguez-Abreu, C.
Journal of Molecular Liquids, 343, art. no. 117594, 2021
- Chromonic Nematic Liquid Crystals in a Room-Temperature Ionic Liquid-
Jose Rodrigo Magana, Adrià Pérez-Calm and Carlos Rodríguez-Abreu
Chem. Commun., 2022
- Systematic study of chromonic liquid crystal-based complex emulsions and their application in the preparation of silica nanomaterials-
Adrià Pérez-Calm, Yury V. Kolen’ko, Laura M. Salonen, Hugo Busson, Jordi Esquena, Carlos Rodríguez-Abreu
Colloids andSurfacesA:PhysicochemicalandEngineeringAspects699(2024)134723
- Engineering ternary systems as non-viral vehicles for transporting floxuridine oligomer-
Margaux Staëlen, Victor Espinosa, Margot Jacquemet, Anna Aviñó, María José García-Celma, Ramon Eritja, Carlos Rodriguez-Abreub, Santiago Grijalvo
European Polymer Journal, Volume 216, 7 August 2024, 113285 - Rosmarinic Acid-Loaded Polymeric Nanoparticles Prepared by Low-Energy Nano-Emulsion Templating: Formulation, Biophysical Characterization, and In Vitro Studies-
García-Melero, J., López-Mitjavila, J.-J., García-Celma, M.J., Rodriguez-Abreu, C., Grijalvo, S.
Materials, 15 (13), art. no. 4572, 2022
- A post-synthetic modification strategy for the synthesis of pyrene-fused azaacene covalent organic frameworks-
Fernandes, S.P.S., Frey, L., Cid-Seara, K.M., Oliveira, O., Guldris, N., Carbó-Argibay, E., Rodríguez-Abreu, C., Kolen'ko, Y.V., Silva, A.M.S., Medina, D.D., Salonen, .M.
Microporous and Mesoporous Materials, 343, art. no. 112162, 2022
- Ferulic acid-loaded polymeric nanoparticles prepared from nano-emulsion templates facilitate internalisation across the blood-brain barrier in model membranes-
Garcia, L., Palma-Florez, S., Espinosa, V., Soleimani Rokni, F., Lagunas, A., Mir, M., García-Celma, M.J., Samitier, J., Rodríguez-Abreu, C., Grijalvo, S.
Nanoscale, 15 (17), pp. 7929-7944. 2023
- Electrocatalytic Pt-embedded ZIF-8 on nanocellulose-based flexible conductive electrodes for hydrogen evolution reaction-
Krathumkhet, N., Kao, C.-Y., Imae, T., Rodriguez-Abreu, C.
Cellulose, 30 (5), pp. 3185-3200. 2023
- Unravelling the role of individual components in pBAE/polynucleotide polyplexes in the synthesis of tailored carriers for specific applications: on the road to rational formulations-
Navalón-López, M., Dols-Perez, A., Grijalvo, S., Fornaguera, C., Borrós, S.
Nanoscale Advances, 5 (6), pp. 1611-1623. 2023
- Effect of surface functionalization and loading on the mechanical properties of soft polymeric nanoparticles prepared by nano-emulsion templating-
Dols-Perez, A., Fornaguera, C., Feiner-Gracia, N., Grijalvo, S., Solans, C., Gomila, G.
Colloids and Surfaces B: Biointerfaces, 222, art. no. 113019, .
- Polymer nanoparticles from low-energy nanoemulsions for biomedical applications-
Grijalvo, S., Rodriguez-Abreu, C.
Beilstein Journal of Nanotechnology, 14, pp. 339-350.
- Study of nanoemulsions using carvacrol/MCT-(Oleic acid-potassium oleate)/ Tween 80 ®- water system by low energy method-
Santamaría, E., Maestro, A., Vilchez, S., González, C.
Heliyon, 9 (6), 2023
- EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial-
Verdú-Soriano, J., de Cristino-Espinar, M., Luna-Morales, S., Dios-Guerra, C., Casado-Díaz, A., Quesada-Gómez, J.M., Dorado, G., Berenguer-Pérez, M., Vílchez, S., Esquena, J., Rodríguez-Mañas, L., Lázaro-Martínez, J.L.
Pharmaceutics, 15 (7), art. no. 1925, 2023.
- AYUDAS PROMOCIÓN EMPLEO JOVEN 2018 (AEI)-
Referencia: PEJ2018-001872-P
Financiador: MINISTERIO DE CIENCIA INNOVACIÓN Y UNIVERSIDADES - AGENCIA ESTATAL DE INVESTIGACIÓN; UNIÓN EUROPEA, FONDO SOCIAL EUROPEO (El FSE invietre en tu futuro).
Beneficiario: JOSÉ ANTONIO DURAN GONZÁLEZ.
Comienzo: 01/12/2019 Final: 30/11/2021
- Mesostructured Materials with Controllable Long-Range Orientational Ordering and Anisotropic Properties-
Jahnke, J.P., Kim, D., Wildemuth, D.J., Nolla, J., Berkow, M.W., Gwak, H., Neyshtadt, S., Segal-Peretz, T., Frey, G.L., Chmelka, B.F.
Advanced Materials, 35 (51), art. no. 2306800, 2023 - Surface decoration of PLGA nanoparticles enables efficient transport of floxuridine oligomers into mammalian cells-
Barnaud, L., Fukuhara, S., Pava, M., Carrasco, M., Aviñó, A., Eritja, R., Rodriguez-Abreu, C., Grijalvo, S.
Reactive and Functional Polymers, 202, art. no. 105959, 2024. - Surfactant-mediated gelation by 12-hydroxyoctadecanoic acid in a nonionic surfactant system-
Aramaki, K., Maeda, M., Murokasa, Y., Mata, J., Calderó, G., Rodriguez-Abreu, C.
Colloids and Surfaces A: Physicochemical and Engineering Aspects, 695, art. no. 134258, 2024.
- Formation of water-in-water emulsions and microgels in nonionic surfactant + gelatin aqueous mixtures-
Jonathan Miras, Susana Vílchez, Cyprien Bouju, Martí Blanco-Pérez, Marc Ros-Espinal, Carlos Rodríguez-Abreu, Jordi Esquena
Journal of Colloid and Interface Science, 684, pp. 319-330, 2025
