UNITAT DE RECERCA EN MOLÈCULES BIOACTIVES
El nostre grup té un caràcter multidisciplinari i el seu objectiu és dur a terme projectes d’investigació en la interfície entre la química i la biologia. Específicament, estem involucrats en estudis sobre compostos orgànics biològicament actius amb l’objectiu d’identificar noves molècules d’interès biomèdic i agroquímic.
En el primer cas, els nostres interessos se centren en la química i la biologia dels lípids. Estem particularment interessats en el desenvolupament de sondes químiques per a estudis relacionats amb el metabolisme i les funcions dels esfingolípids i en el descobriment de xaperones farmacològiques com alternatives prometedores per a algunes esfingolipidosis. També estem interessats en el desenvolupament de mètodes de cribratge d’alt rendiment per al descobriment de noves entitats químiques o la reutilització de fàrmacs existents com moduladors del metabolisme dels esfingolípids amb finalitats terapèutiques.
En el camp de l’agroquímica, estem interessats en el desenvolupament de nous mètodes alternatius i no contaminants de control de plagues. Dins d’aquesta línia, els nostres interessos es dirigeixen a la identificació de noves feromones d’insectes plaga i en el desenvolupament d’inhibidors d’enzims implicats en la degradació de les feromones.
La nostra Unitat té àmplia experiència en química biològica, així com un elevat coneixement per abordar el desenvolupament de metodologia de síntesi de molècules, així com estudis sobre el metabolisme lipídic, enzimologia, biologia cel·lular i biologia molecular. Recentment, el grup ha integrat noves tècniques d’anàlisi lliures de marcatges que permeten l’anàlisi directa de biomolècules, així com de la distribució de fàrmacs i metabòlits en els teixits. Les investigacions especialitzades es duen a terme en el marc de col·laboracions amb grups d’investigació amb les instal·lacions i experiència requerides. La participació en projectes de recerca multidisciplinaris en col·laboració amb institucions acadèmiques i públiques, així com amb socis industrials, és un objectiu essencial del grup. Per a més informació, feu clic aquí en anglès a pag externa del grup
Web del grup: www.rubam.net/
Els esfingolípids en biomedicina
Els esfingolípids (SL) regulen les vies de transducció de senyals involucrades en diversos processos biològics. La desregulació del metabolisme dels SL condueix a l’inici i progressió de malalties, des de síndromes minoritaris a trastorns d’alt impacte socioeconòmic. Diversos enzims del metabolisme dels SL han estat validats com a dianes terapèutiques i, per tant, el descobriment de compostos capaços de modular aquestes activitats enzimàtiques és de rellevància farmacològica. Aquests compostos poden sorgir a partir del cribratge de quimioteques, que requereix la disponibilitat de mètodes de d’alt rendiment (HTS), actualment molt escassos. D’altra banda, conèixer els mecanismes moleculars implicats en les funcions dels SL pot conduir a la identificació de noves dianes terapèutiques. Aquesta línia abasta la síntesi química de molècules de petit pes molecular i l’estudi de les seves activitats en diferents contextos biològics. Veure més enllaç a pag externa del grup.
Ecologia química
Aquesta línia aborda diferents aspectes relacionats amb noves feromones d’insectes plaga, des de la seva caracterització estructural i la síntesi de feromones i anàlegs i la seva activitat en el laboratori mitjançant tècniques d’electrofisiologia i bioassaigs de comportament a proves de camp. També estem compromesos amb el desenvolupament de noves alternatives i no contaminants per al control de plagues agroforestals basades en la inhibició dels enzims responsables de la degradació de les molècules de feromones en les antenes dels insectes. Veure més enllaç a pag externa del grup.
Òmica & Imatge: desenvolupament i aplicació d’eines i mètodes analítics
Aquesta línia té com a objectiu el desenvolupament d’eines químiques i mètodologies per determinar les composicions de metabòlits (metabolòmica), lípids (lipidómica) i proteïnes (proteòmica) i els canvis en els seus perfils provocats per estímuls i condicions variades. En els nostres estudis s’utilitzen tècniques d’espectrometria de masses acoblades a sistemes cromatogràfics(GC-MS i LC-MS), així com la imatge per espectrometria de masses MALDI. En col·laboració amb el Prof. Romà Tauler (IDAEA-CSIC), aquest línia també inclou l’aplicació de mètodes quimiomètrics i multivariants moderns i potents d’anàlisi de dades.
Les nostres infraestructures i experiència també s’ofereixen a grups externs d’institucions privades i públiques.
Per a més informació, web del grup: https://rubam.net
Personal científic
Gemma Fabriàs
Professor Investigació
gemma.fabrias@iqac.csic.es
Josefina Casas
Investigador Científic
josefina.casas@iqac.csic.es
José Luis Abad
Científic Titular
joseluis.abad@iqac.csic.es
Antonio Delgado
Professor de química, UB
antonio.delgado@iqac.csic.es
Personal de laboratori
Carme Quero López
Titulat Superior
carme.quero@iqac.csic.es
Mireia Casasampere
Investigador postdoctoral
mireia.casasampere@iqac.csic.es
Sergio López
Investigador Postdoctoral
sergio.lopez@iqac.csic.es
Hector Carneros
Investigador postdoctoral
hector.carneros@iqac.csic.es
Mazen Aseeri
Investigador predoctoral
mazen.aseeri@iqac.csic.es
Abdulateef Saeed Alqahtani
Investigador predoctoral
abdulateef.saeed@iqac.csic.es
Eva Dalmau
Tècnic
eva.dalmau@iqac.csic.es
Alejandro Iñañez
Tècnic
alejandro.inanez@iqac.csic.es
Mª Carmen Rozalén
Tècnic
carmen.rozalen@iqac.csic.es
- Targeted nanoliposomes to improve enzyme replacement therapy of Fabry disease-
Tomsen-Melero, Judit, Moltó-Abad, Marc, Merlo-Mas, Josep, Díaz-Riascos, Zamira V., Cristóbal-Lecina, Edgar, Soldevila, Andreu, Altendorfer-Kroath, Thomas, Danino, Dganit, Ionita, Inbal, Andersen, Jan Skov, Snelling, Lyndsey, Clay, Hazel, Carreño, Aida, Corchero, José L., Pulido, Daniel, Casas, Josefina, Veciana, Jaume, Schwartz, Simó, Sala, Santi, Font, Albert, Birngruber, Thomas, Royo, Miriam, Córdoba, Alba, Ventosa, Nora, Abasolo, Ibane, González-Mira, Elisabet
Science Advances, Vol 10, Issue 5013, 2024, Article number eadq4738
- Aptamer-Hytac Chimeras for Targeted Degradation of SARS-CoV-2 Spike-1-
Fàbrega, Carme; Gallisà-Suñé, Núria; Zuin, Alice; Ruíz, Juan Sebastián; Coll-Martínez, Bernat; Fabriàs, Gemma; Eritja, Ramon; Crosas, Bernat
Cells, Volume 13, Issue 21, November 2024 Article number 1767 - In vitro and in vivo studies of ocular topically administered NLC for the treatment of uveal melanoma-
Cinzia Cimino, Elena Sánchez López, Angela Bonaccorso, Lorena Bonilla, Teresa Musumeci, Josefa Badia, Laura Baldomà, Rosario Pignatello, Agostino Marrazzo, Carla Barbaraci, María Luisa García, Claudia Carbone
International Journal of Pharmaceutics, Volume 660, 20, 124300 - Small and Large Extracellular Vesicles of Porcine Seminal Plasma Differ in Lipid Profile-
Pablo Martínez-Díaz, Ana Parra, Christian M. Sanchez-López, Josefina Casas, Xiomara Lucas, Antonio Marcilla, Jordi Roca and Isabel Barranco
J. Mol. Sci. 2024, 25, 7492. https://doi.org/10.3390/ijms25137492 - A shift in the paradigm? A male-specific lactone increases the response of both sexes of the olive fruit fly Bactrocera oleae to the food lure ammonium bicarbonate-
López, S., Acín, P., Gómez-Zubiaur, A., Corbella-Martorell, C., Quero, C.
Journal of Pest Science, 97 (2), pp. 965-978. 2024
- A fluorogenic substrate for the detection of lipid amidases in intact cells-
Casasampere, M., Ung, J., Ináñez, A., Dufau, C., Tsuboi, K., Casas, J., Tan, S.-F., Feith, D.J., Andrieu-Abadie, N., Segui, B., Loughran, T.P., Abad, J.L., Fabrias, G.
Journal of Lipid Research, 65 (3), art. no. e100520, 2024.
- Targeting dihydroceramide desaturase 1 (Des1): Syntheses of ceramide analogues with a rigid scaffold, inhibitory assays, and AlphaFold2-assisted structural insights reveal cyclopropenone PR280 as a potent inhibitor-
Rivero, P., Ivanova, V., Barril, X., Casampere, M., Casas, J., Fabriàs, G., Díaz, Y., Matheu, M.I.
Bioorganic Chemistry, 145, art. no. 107233, 2024.
- Non-target ROIMCR LC–MS analysis of the disruptive effects of TBT over time on the lipidomics of Daphnia magna-
Jafari, J.M., Casas, J., Barata, C., Abdollahi, H., Tauler, R.
Metabolomics, 19 (8), art. no. 70, 2023.
- RINT1 deficiency disrupts lipid metabolism and underlies a complex hereditary spastic paraplegia-
Launay, N., Ruiz, M., Planas-Serra, L., Verdura, E., Rodríguez-Palmero, A., Schlüter, A., Goicoechea, L., Guilera, C., Casas, J., Campelo, F., Jouanguy, E., Casanova, J.-L. Boespflug-Tanguy, O., Cancela, M.V., z-Solana, L.G.G., Casasnovas, C., Area-Gomez, E., Pujol, A.
Journal of Clinical Investigation, 133 (14), art. no. e162836, 2023.
- β-Cyclodextrins as affordable antivirals to treat coronavirus infection-
Raïch-Regué, D., Tenorio, R., Fernández de Castro, I., Tarrés-Freixas, F., Sachse, M., Perez-Zsolt, D., Muñoz-Basagoiti, J., Fernández-Sánchez, S.Y., Gallemí, M., Ortega-González, P., Fernández-Oliva, A., Gabaldón, J.A., Nuñez-Delicado, E., Casas, J., Roca, N., Cantero, G., Pérez, M., Usai, C., Lorca-Oró, C., Alert, J.-V., Segalés, J., Carrillo, J., Blanco, J., Clotet Sala, B., Cerón-Carrasco, J.P., Izquierdo-Useros, N., Risco, C.
Biomedicine and Pharmacotherapy, 164, 2023
- Lipid signatures of West Nile virus infection unveil alterations of sphingolipidmetabolism providing novel biomarkers-
Patricia Mingo-Casas, Javier Sanchez-Céspedes, Ana-Belén Blázquez, Josefina Casas, María Balsera-Manzanero, Laura Herrero, Ana Vázquez, Jerónimo Pachón, Manuela Aguilar-Guisado, José Miguel Cisneros, Juan-Carlos Saiz and Miguel A. Martín-Acebes
Emerging Microbes & Infections, 2023, VOL. 12, 2231556
- Contact chemoreceptive mate recognition in Cerambyx welensii Küster (Coleoptera: Cerambycidae)-
Sánchez-Osorio, I., López-Pantoja, G., Domínguez, L., López-Manzano, M.R., Rosell, G., Guerrero, Á.
Agricultural and Forest Entomology, 25 (4), pp. 622-636. 2023
- Obesity promotes fumonisin B1 hepatotoxicity-
Dopavogui, L., Régnier, M., Polizzi, A., Ponchon, Q., Smati, S., Klement, W., Lasserre, F., Lukowicz, C., Lippi, Y., Fougerat, A., Bertrand-Michel, J., Naylies, C., Canlet, C., Debrauwer, L., Rousseau-Bacquié, E., Gamet-Payrastre, L., Dauriat, C., Casas, J., Croubels, S., De Baere, S., Burger, H.M., Chassaing, B., Ellero-Simatos, S., Guillou, H., Oswald, I.P., Loiseau, N.
Science of the Total Environment, 891, 2023
- Modulation of Dietary Choline Uptake in a Mouse Model of Acid Sphingomyelinase Deficiency-
Gaudioso, Á., Moreno-Huguet, P., Casas, J., Schuchman, E.H., Ledesma, M.D.
International Journal of Molecular Sciences, 24 (11), 2023
- Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation-
Smith, C.J., Williams, J.L., Hall, C., Casas, J., Caley, M.P., O'Toole, E.A., Prasad, R., Metherell, L.A.
Journal of Lipid Research, 64 (4), art. no. 100351, 2023.
- Sphingomyelin 16:0 is a therapeutic target for neuronal death in acid sphingomyelinase deficiency-
Gaudioso, Á., Jiang, X., Casas, J., Schuchman, E.H., Ledesma, M.D.
Cell Death and Disease, 14 (4), art. no. 248, 2023.
- Simultaneous Inhibition of Ceramide Hydrolysis and Glycosylation Synergizes to Corrupt Mitochondrial Respiration and Signal Caspase Driven Cell Death in Drug-Resistant Acute Myeloid Leukemia-
Fisher-Wellman, K.H., Kassai, M., Hagen, J.T., Neufer, P.D., Kester, M., Loughran, T.P., Chalfant, C.E., Feith, D.J., Tan, S.-F., Fox, T.E., Ung, J., Fabrias, G., Abad, J.L., Sharma, A., Golla, U., Claxton, D.F., Shaw, J.J.P., Bhowmick, D., Cabot, M.C.
Cancers, 15 (6), art. no. 1883, 2023.
- Pharmacological Elevation of Cellular Dihydrosphingomyelin Provides a Novel Antiviral Strategy against West Nile Virus Infection-
Jiménez de Oya, N., San-Félix, A., Casasampere, M., Blázquez, A.-B., Mingo-Casas, P., Escribano-Romero, E., Calvo-Pinilla, E., Poderoso, T., Casas, J., Saiz, J.-C., Pérez-Pérez, M.-J., Martín-Acebes, M.A.
Antimicrobial agents and chemotherapy, 67 (4), p. e0168722. 2023
- Laboratory Evidence of 2-Isobutyl-3-methoxypyrazine as a Male-Released Aggregative Cue in Labidostomis lusitanica (Germar) (Coleoptera: Chrysomelidae)-
López, S., Rodrigo-Gómez, S., Fernández-Carrillo, E., Corbella-Martorell, C., Quero, C.
Insects, 14 (2), art. no. 107, 2023.
- Cpt1c Downregulation Causes Plasma Membrane Remodelling and Anthracycline Resistance in Breast Cancer-
Muley, H., Valencia, K., Casas, J., Moreno, B., Botella, L., Lecanda, F., Fadó, R., Casals, N.
International Journal of Molecular Sciences, 24 (2), art. no. 946, 2023.
- High-throughput discovery of novel small-molecule inhibitors of acid Ceramidase-
Aseeri, M., Abad, J.L., Delgado, A., Fabriàs, G., Triola, G., Casas, J.
Journal of Enzyme Inhibition and Medicinal Chemistry, 38 (1), pp. 343-348.
- Fluorescently Labeled Ceramides and 1-Deoxyceramides: Synthesis, Characterization, and Cellular Distribution Studies-
Eduardo Izquierdo, Marta López-Corrales, Diego Abad-Montero, Anna Rovira, Gemma Fabriàs, Manel Bosch, José Luís Abad*, and Vicente Marchán
J. Org. Chem. 2022
- Methuosis Contributes to Jaspine-B-Induced Cell Death-
Bielsa, N., Casasampere, M., Abad, J.L., Enrich, C., Delgado, A., Fabriàs, G., Lizcano, J.M., Casas, J.
International Journal of Molecular Sciences, 23 (13), art. no. 7257, 2022
- Olean (1,7-dioxaspiro[5.5]undecane): A Novel Intraspecific Chemical Cue in Coraebus undatus (F.) (Coleoptera: Buprestidae)-
Sergio López, José María Álvarez-Calero, Josep Maria Riba-Flinch, María Milagro Coca-Abia, Antoni Torrell and Carmen Quero
Insects 2021, 12(12), 1085
- Chirality-Puckering correlation and intermolecular interactions in Sphingosines: Rotational spectroscopy of jaspine B3 and its monohydrate-
Saragi, R.T., Juanes, M., Abad, J.L., Pinacho, R., Rubio, J.E., Lesarri, A.
Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, 267, art. no. 120531, 2021
- Development of Novel Management Tools for Phortica variegata (Diptera: Drosophilidae), Vector of the Oriental Eyeworm, Thelazia callipaeda (Spirurida: Thelaziidae), in Europe-
M A González, D Bravo-Barriga, P M Alarcón-Elbal, J M Álvarez-Calero, C Quero, M Ferraguti, S López
Journal of Medical Entomology, 2021;, tjab171, https://doi.org/10.1093/jme/tjab171
- Diets with higher ω-6/ω-3 ratios show differences in ceramides and fatty acid levels accompanied by increased amyloid-beta in the brains of male APP/PS1 transgenic mice-
Ordóñez-Gutiérrez, L., Fábrias, G., Casas, J., Wandosell, F.
International Journal of Molecular Sciences, 22 (20), art. no. 10907, 2021
- Inhibition of sphingosine 1-phosphate protects mice against chondrocyte catabolism and osteoarthritis-
Cherifi, C., Latourte, A., Vettorazzi, S., Tuckermann, J., Provot, S., Ea, H.-K., Ledoux, A., Casas, J., Cuvillier, O., Richette, P., Ostertag, A., Hay, E., Cohen-Solal, M.
Osteoarthritis and Cartilage, 29 (9), pp. 1335-1345. 2021
- Latest developments in insect sex pheromone research and its application in agricultural pest management-
Rizvi, S.A.H., George, J., Reddy, G.V.P., Zeng, X., Guerrero, A.
Insects, 12 (6), art. no. 484, 2021,
- Extracellular vesicles from recombinant cell factories improve the activity and efficacy of enzymes defective in lysosomal storage disorders-
Seras-Franzoso, J., Díaz-Riascos, Z.V., Corchero, J.L., González, P., García-Aranda, N., Mandaña, M., Riera, R., Boullosa, A., Mancilla, S., Grayston, A., Moltó-Abad, M., Garcia-Fruitós, E., Mendoza, R., Pintos-Morell, G., Albertazzi, L., Rosell, A., Casas, J., Villaverde, A., Schwartz, S., Abasolo, I.
Journal of Extracellular Vesicles, 10 (5), art. no. e12058, . 2021
- Discovery of deoxyceramide analogs as highly selective ACER3 inhibitors in live cells-
Núria Bielsa, Mireia Casasampere, Mazen Aseeri, Josefina Casas, Antonio Delgado, José Luis Abad, GemmaFabrià
European Journal of Medicinal Chemistry, 216, 2021
- Synthesis and characterization of bichromophoric 1-deoxyceramides as FRET probes-
Izquierdo, E., Casasampere, M., Fabriàs, G., Abad, J.L., Casas, J., Delgado, A.
Organic and Biomolecular Chemistry, 19 (11), pp. 2456-2467. 2021
- HDAC11 is a novel regulator of fatty acid oxidative metabolism in skeletal muscle-
Hurtado, E., Núñez-Álvarez, Y., Muñoz, M., Gutiérrez-Caballero, C., Casas, J., Pendás, A.M., Peinado, M.A., Suelves, M.
FEBS Journal, 288 (3), pp. 902-919. 2021
- Carnitine palmitoyltransferase 1C negatively regulates the endocannabinoid hydrolase ABHD6 in mice, depending on nutritional status-
Miralpeix, C., Reguera, A.C., Fosch, A., Casas, M., Lillo, J., Navarro, G., Franco, R., Casas, J., Alexander, S.P.H., Casals, N., Rodríguez-Rodríguez, R.
British Journal of Pharmacology, 2021
- Inhibitory effect of thymol on pheromone-mediated attraction in two pest moth species-
López, S., Domínguez, A., Guerrero, Á., Quero, C.
Scientific Reports, 11 (1), art. no. 1223,
- Cholesterol in the Viral Membrane is a Molecular Switch Governing HIV-1 Env Clustering-
Nieto-Garai, J.A., Arboleya, A., Otaegi, S., Chojnacki, J., Casas, J., Fabriàs, G., Contreras, F.-X., Kräusslich, H.-G., Lorizate, M.
Advanced Science, 2020
- Click and count: Specific detection of acid ceramidase activity in live cells-
Casasampere, M., Izquierdo, E., Casas, J., Abad, J.L., Liu, X., Xu, R., Mao, C., Chang, Y.-T., Delgado, A., Fabrias, G.
Chemical Science, 11 (48), pp. 13044-13051. 2020
- The Potential of Proteolytic Chimeras as Pharmacological Tools and Therapeutic Agents-
Coll-Martínez, B., Delgado, A., Crosas, B.
Molecules (Basel, Switzerland), 25 (24), .2020
- β-galactosylceramidase promotes melanoma growth via modulation of ceramide metabolism-
Belleri, M., Paganini, G., Coltrini, D., Ronca, R., Zizioli, D., Corsini, M., Barbieri, A., Grillo, E., Calza, S., Bresciani, R., Maiorano, E., Mastropasqua, M.G., Annese, T., Giacomini, A., Ribatti, D., Casas, J.,
Cancer Research, 80 (22), pp. 5011-5023. 2020
- Biophysical and lipidomic biomarkers of cardiac remodeling post-myocardial infarction in humans-
Samouillan, V., Samper, I.M.M.L., Amaro, A.B., Vilades, D., Dandurand, J., Casas, J., Jorge, E., Calvo, D.G., Gallardo, A., Lerma, E., Ramos, J.M.G., Carreras, F., Leta, R., Cortes, V.L.
Biomolecules, 10 (11), art. no. 1471, pp. 1-20. 2020
- Avian Feeding Preferences of Culex pipiens and Culiseta spp. Along an Urban-to-Wild Gradient in Northern Spain-
González, M.A., Prosser, S.W., Hernández-Triana, L.M., Alarcón-Elbal, P.M., Goiri, F., López, S., Ruiz-Arrondo, I., Hebert, P.D.N., García-Pérez, A.L.
Frontiers in Ecology and Evolution, 8, art. no. 568835, 2020
- Inhibition of fatty acid amide hydrolase prevents pathology in neurovisceral acid sphingomyelinase deficiency by rescuing defective endocannabinoid signaling-
Bartoll, A., Toledano-Zaragoza, A., Casas, J., Guzmán, M., Schuchman, E.H., Ledesma, M.D.
EMBO Molecular Medicine, 12 (11), art. no. E11776, 2020.
- Expanding the clinical and genetic spectrum of PCYT2-related disorders-
Vélez-Santamaría, V., Verdura, E., Macmurdo, C., Planas-Serra, L., Schlüter, A., Casas, J., Martínez, J.J., Casasnovas, C., Si, Y., Thompson, S.S., Maroofian, R., Pujol, A.
Brain : a journal of neurology, 143 (9), p. e76. 2020
- Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction-
Maharaj, A., Williams, J., Bradshaw, T., Güran, T., Braslavsky, D., Casas, J., Chan, L.F., Metherell, L.A., Prasad, R.
Journal of Steroid Biochemistry and Molecular Biology, 202, art. no. 105730, 2020 - Eco-friendly printing paste replacing urea-based formulations in cotton printing-
Vílchez, S., López, A., Miras, J., Bleda, M.J., Manich, A.M., Puigventós, N., Genís, E., Esquena, J.
Journal of the Textile Institute, 2020
- Two chiral types of randomly rotated ommatidia are distributed across the retina of the flathead oak borer Coraebus undatus (Coleoptera: Buprestidae)-
Meglič, A., Ilić, M., Quero, C., Arikawa, K., Belušič, G.
The Journal of experimental biology, 223, 2020
- Liver CPT1A gene therapy reduces diet-induced hepatic steatosis in mice and highlights potential lipid biomarkers for human NAFLD-
Weber, M., Mera, P., Casas, J., Salvador, J., Rodríguez, A., Alonso, S., Sebastián, D., Soler-Vázquez, M.C., Montironi, C., Recalde, S., Fucho, R., Calderón-Domínguez, M., Mir, J.F., Bartrons, R., Escola-Gil, J.C., Sánchez-Infantes, D., Zorzano, A., Llorente-Cortes, V., Casals, N., Valentí, V., Frühbeck, G., Herrero, L., Serra, D.
FASEB Journal, 2020
- Myriocin-induced adaptive laboratory evolution of an industrial strain of Saccharomyces cerevisiae reveals its potential to remodel lipid composition and heat tolerance-
Randez-Gil, F., Prieto, J.A., Rodríguez-Puchades, A., Casas, J., Sentandreu, V., Estruch, F.
Microbial Biotechnology, 13 (4), pp. 1066-1081. 2020
- CCR5 deficiency impairs CD4+ T-cell memory responses and antigenic sensitivity through increased ceramide synthesis-
Martín-Leal, A., Blanco, R., Casas, J., Sáez, M.E., Rodríguez-Bovolenta, E., de Rojas, I., Drechsler, C., Real, L.M., Fabrias, G., Ruíz, A., Castro, M., Schamel, W.W.A., Alarcón, B., van Santen, H.M., Mañes, S.
EMBO Journal, 2020
- The anti-cancer drug ABTL0812 induces ER stress-mediated cytotoxic autophagy by increasing dihydroceramide levels in cancer cells-
Muñoz-Guardiola, P., Casas, J., Megías-Roda, E., Solé, S., Perez-Montoyo, H., Yeste-Velasco, M., Erazo, T., Diéguez-Martínez, N., Espinosa-Gil, S., Muñoz-Pinedo, C., Yoldi, G., Abad, J.L., Segura, M.F., Moran, T., Romeo, M., Bosch-Barrera, J., Oaknin, A., Alfón, J., Domènech, C., Fabriàs, G., Velasco, G., Lizcano, J.M.
Autophagy 2020
- Myriocin‐induced adaptive laboratory evolution of an industrial strain of Saccharomyces cerevisiae reveals its potential to remodel lipid composition and heat tolerance-
Randez-Gil, F., Prieto, J.A., Rodríguez-Puchades, A., Casas, J., Sentandreu, V., Estruch, F.
Microbial Biotechnology, 2020
- Ceramide Analogue SACLAC Modulates Sphingolipid Levels and MCL-1 Splicing to Induce Apoptosis in Acute Myeloid Leukemia-
Pearson, J.M., Tan, S.-F., Sharma, A., Annageldiyev, C., Fox, T.E., Abad, J.L., Fabrias, G., Desai, D., Amin, S., Wang, H.-G., Cabot, M.C., Claxton, D.F., Kester, M., Feith, D.J., Loughran, T.P.
Molecular Cancer Research, 18 (3), pp. 352-363 2020
- A Mechanism-Based Sphingosine-1-phosphate Lyase Inhibitor-
Pons, G., Riba, D., Casasampere, M., Izquierdo, E., Abad, J.-L., Fabriàs, G., Rodríguez Ortega, P.G., López-González, J.J., Montejo, M., Casas, J., Delgado, A.
Journal of Organic Chemistry, 85 (2), pp. 419-429. 2020
- Ovarian Hormone-Dependent Effects of Dietary Lipids on APP/PS1 Mouse Brain-
Herrera, J.L., Ordoñez-Gutierrez, L., Fabrias, G., Casas, J., Morales, A., Hernandez, G., Acosta, N.G., Rodriguez, C., Prieto-Valiente, L., Garcia-Segura, L.M., Wandosell, F.G., Alonso, R.
Frontiers in Aging Neuroscience, 11, art. no. 346, 2019
- Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells-
Meneses-Salas, E., García-Melero, A., Kanerva, K., Blanco-Muñoz, P., Morales-Paytuvi, F., Bonjoch, J., Casas, J., Egert, A., Beevi, S.S., Jose, J., Llorente-Cortés, V., Rye, K.-A., Heeren, J., Lu, A., Pol, A., Tebar, F., Ikonen, E., Grewal, T., Enrich, C., Rentero, C.
Cellular and Molecular Life Sciences, 77 (14), pp. 2839-2857 2020
- Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells-
Meneses-Salas, E., García-Melero, A., Kanerva, K., Blanco-Muñoz, P., Morales-Paytuvi, F., Bonjoch, J., Casas, J., Egert, A., Beevi, S.S., Jose, J., Llorente-Cortés, V., Rye, K.-A., Heeren, J., Lu, A., Pol, A., Tebar, F., Ikonen, E., Grewal, T., Enrich, C., Rentero, C.
Cellular and Molecular Life Sciences 2019
- Adeno-associated viral vector serotype 9–based gene therapy for Niemann-Pick disease type A-
Samaranch, L., Pérez-Cañamás, A., Soto-Huelin, B., Sudhakar, V., Jurado-Arjona, J., Hadaczek, P., Ávila, J., Bringas, J.R., Casas, J., Chen, H., He, X., Schuchman, E.H., Cheng, S.H., Forsayeth, J., Bankiewicz, K.S., Ledesma, M.D.
Science Translational Medicine, 11 (506), art. no. eaat3738, . 2019
- Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells-
Kester, M., Loughran, T.P., Abad, J.L., Fabrias, G., Tan, S.-F., Feith, D.J., Claxton, D.F., Spiegel, S., Fisher-Wellman, K.H., Cabot, M.C.
Journal of Lipid Research, 60 (9), pp. 1590-1602. 2019
- Rotational spectroscopy of organophosphorous chemical agents: cresyl and phenyl saligenin phosphates-
Saragi, R.T., Juanes, M., Abad, J.L., Lesarri, A., Pinacho, R., Rubio, J.E.
Physical chemistry chemical physics : PCCP, 21 (30), pp. 16418-16422. 2019
- A proteomic analysis of the statocyst endolymph in common cuttlefish (Sepia officinalis): an assessment of acoustic trauma after exposure to sound-
M. Solé, M. Monge, M. André & C. Quero
Scientific Reportsvolume 9, Article number: 9340, 2019
- Regulation of Serum Sphingolipids in Andean Children Born and Living at High Altitude (3775 m)-
Barbacini, P., Casas, J., Torretta, E., Capitanio, D., Maccallini, G., Hirschler, V., Gelfi, C.
International journal of molecular sciences, 20 (11), . 2019
- New fluorogenic probes for neutral and alkaline ceramidases-
Casasampere, M., Bielsa, N., Riba, D., Bassas, L., Xu, R., Mao, C., Fabriàs, G., Abad, J.-L., Delgado, A., Casas, J.
Journal of Lipid Research, 60 (6), pp. 1174-1181. 2019
- Hypothalamic endocannabinoids inversely correlate with the development of diet-induced obesity in male and female mice-
Miralpeix, C., Fosch, A., Casas, J., Baena, M., Herrero, L., Serra, D., Rodríguez-Rodríguez, R., Casals, N.
Journal of Lipid Research, 60 (7), pp. 1260-1269. 2019
- Activity-Based Imaging of Acid Ceramidase in Living Cells-
Yadira F. Ordóñez, José Luís Abad, Mazen Aseer, Josefina Casas, Virginie Garcia, Mireia Casasampere, Edward H. Schuchman, Thierry Levade, Antonio Delgado, Gemma Triola and Gemma Fabrias
J. Am. Chem. Soc., 2019
- Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models-
Jiménez de Oya, N., Esler, W.P., Huard, K., El-Kattan, A.F., Karamanlidis, G., Blázquez, A.-B., Ramos-Ibeas, P., Escribano-Romero, E., Louloudes-Lázaro, A., Casas, J., Sobrino, F., Hoehn, K., James, D.E., Gutiérrez-Adán, A., Saiz, J.-C., Martín-Acebes, M.A.
Emerging Microbes and Infections, 8 (1), pp. 624-636., 2019
- SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism-
Benson, S., Fernandez, A., Barth, N.D., de Moliner, F., Horrocks, M.H., Herrington, C.S., Abad, J.L., Delgado, A., Kelly, L., Chang, Z., Feng, Y., Nishiura, M., Hori, Y., Kikuchi, K., Vendrell, M.
Angewandte Chemie - International Edition, .2019
- Ceramide Imbalance and Impaired TLR4-Mediated Autophagy in BMDM of an ORMDL3-Overexpressing Mouse Model-
Kiefer, K., Casas, J., García-López, R., Vicente, R.
International journal of molecular sciences, 20 (6), 2019
- Enantioselective Synthesis and Activity of All Diastereoisomers of (E)-Phytal, a Pheromone Component of the Moroccan Locust, Dociostaurus maroccanus-
Angel Guerrero, Victoria Elena Ramos, Sergio López, José María Álvarez-Calero, Aroa Dominguez, Mª Milagro Coca, Mª Pilar Bosch, and Carmen Quero
J. Agric. Food Chem. 2018
- Click chemistry in sphingolipid research-
Izquierdo, E., Delgado, A.
Chem Phys Lipids 2018, 215, 71-83.
- Clearly Detectable, Kinetically Restricted Solid-Solid Phase Transition in cis-Ceramide Monolayers-
Fanani, M.L., Busto, J.V., Sot, J., Abad, J.L., Fabrías, G., Saiz, L., Vilar, J.M.G., Goñi, F.M., Maggio, B., Alonso, A.
Langmuir, 34 (39), pp. 11749-11758. 2018
- Functional Effects of the Buckwheat Iminosugar d-Fagomine on Rats with Diet-Induced Prediabetes-
Ramos-Romero, S., Hereu, M., Atienza, L., Casas, J., Taltavull, N., Romeu, M., Amézqueta, S., Dasilva, G., Medina, I., Torres, J.L.
Molecular Nutrition and Food Research, 62 (16), art. no. 1800373, 2018
- SOD3 improves the tumor response to chemotherapy by stabilizing endothelial HIF-2α-
Mira, E., Carmona-Rodríguez, L., Pérez-Villamil, B., Casas, J., Fernández-Aceñero, M.J., Martínez-Rey, D., Martín-González, P., Heras-Murillo, I., Paz-Cabezas, M., Tardáguila, M., Oury, T.D., Martín-Puig, S., Lacalle, R.A., Fabriás, G., Díaz-Rubio, E., Mañes, S.
Nature commun 2018, 9 (1), art. no. 575.
- Ovarian function modulates the effects of long-chain polyunsaturated fatty acids on the mouse cerebral cortex-
Herrera, J.L., Ordoñez-Gutierrez, L., Fabrias, G., Casas, J., Morales, A., Hernandez, G., Acosta, N.G., Rodriguez, C., Prieto-Valiente, L., Garcia-Segura, L.M., Alonso, R., Wandosell, F.G.Front Cell Neurosci, 12, art. no. 103, (2018) .
- Analysis of the neurotoxic effects of neuropathic organophosphorus compounds in adult zebrafish-
Faria, M., Fuertes, I., Prats, E., Abad, J.L., Padrós, F., Gomez-Canela, C., Casas, J., Estevez, J., Vilanova, E., Piña, B., Raldúa, D.
Scientific Reports 2018, 8 (1), art. no. 4844.
- Dihydroceramide Desaturase 1 Inhibitors Reduce Amyloid-β Levels in Primary Neurons from an Alzheimer’s Disease Transgenic Model-
Ordóñez-Gutiérrez, L.; Benito-Cuesta, I.; Abad, J. L.; Casas, J.; Fábrias, G.; Wandosell, F.
Pharm. Res. 2018, 35 (3), 49.
- Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex-
Mir, J.F., Zagmutt, S., Lichtenstein, M.P., García-Villoria, J., Weber, M., Gracia, A., Fabriàs, G., Casas, J., López, M., Casals, N., Ribes, A., Suñol, C., Herrero, L., Serra, D.Mol Neurobiol pp. 1-13. Feb 2, 2018.
- Oleic acid chlorohydrin, a new early biomarker for the prediction of acute pancreatitis severity in humans-
de-Madaria, E., Molero, X., Bonjoch, L., Casas, J., Cárdenas-Jaén, K., Montenegro, A., Closa, D.
Annals of Intensive Care 2018, 8 (1), art. no. 1.
- Jaspine B induces nonapoptotic cell death in gastric cancer cells independently of its inhibition of ceramide synthase-
Cingolani, F.; Simbari, F.; Abad, J. L.; Casasampere, M.; Fabrias, G.; Futerman, A. H.; Casas, J.
- Lipid Res. 2017, 58, 1500–1513.
- Stereodivergent Synthesis of Right- and Left-Handed Iminoxylitol Heterodimers and Monomers. Study of Their Impact on Beta-Glucocerebrosidase Activity.-
Stauffert, F.; Serra-Vinardell, J.; Gómez-Grau, M.; Michelakakis, H.; Mavridou, I.; Grinberg, D.; Vilageliu, L.; Casas, J.; Bodlenner, A.; Delgado, A.; Compain, P.
Org. Biomol. Chem. 2017, 15 (17), 3681–3705.
- The First Fluorogenic Sensor for Sphingosine-1-Phosphate Lyase Activity in Intact Cells.-
Sanllehí, P.; Casasampere, M.; Abad, J.-L.; Fabriàs, G.; López, O.; Bujons, J.; Casas, J.; Delgado, A.
Chem. Commun. 2017, 53 (39), 5441–5444.
- Stereoselective Preparation of Quaternary 2-Vinyl Sphingosines and Ceramides and Their Effect on the Basal Sphingolipid Metabolism.-
Calderón, R.; Mercadal, N.; Abad, J.-L.; Ariza, X.; Delgado, A.; García, J.; Rodríguez, A.; Fabriàs, G.
Chem Phys Lipids 2017, 205, 34–41
- New Murine Niemann-Pick Type C Models Bearing a Pseudoexon-Generating Mutation Recapitulate the Main Neurobehavioural and Molecular Features of the Disease.-
Gómez-Grau, M.; Albaigès, J.; Casas, J.; Auladell, C.; Dierssen, M.; Vilageliu, L.; Grinberg, D.
Sci. Rep. 2017, 7, 41931.
- Acid Ceramidase Deficiency in Mice Results in a Broad Range of Central Nervous System Abnormalities.-
Sikora, J.; Dworski, S.; Jones, E. E.; Kamani, M. A.; Micsenyi, M. C.; Sawada, T.; Le Faouder, P.; Bertrand-Michel, J.; Dupuy, A.; Dunn, C. K.; Xuan, I. C. Y.; Casas, J.; Fabrias, G.; Hampson, D. R.; Levade, T.; Drake, R. R.; Medin, J. A.; Walkley, S. U.
Am. J. Pathol. 2017, 187 (4), 864–883.
- From the Configurational Preference of Dihydroceramide Desaturase-1 towards Δ6-Unsaturated Substrates to the Discovery of a New Inhibitor.-
Pou, A.; Abad, J.-L.; Ordóñez, Y. F.; Garrido, M.; Casas, J.; Fabriàs, G.; Delgado, A.
Chem. Commun. 2017, 53 (31), 4394–4397.
- Mitochondrial GSH Replenishment as a Potential Therapeutic Approach for Niemann Pick Type C Disease-
Torres, S.; Matías, N.; Baulies, A.; Nuñez, S.; Alarcon-Vila, C.; Martinez, L.; Nuño, N.; Fernandez, A.; Caballeria, J.; Levade, T.; Gonzalez-Franquesa, A.; Garcia-Rovés, P.; Balboa, E.; Zanlungo, S.; Fabrías, G.; Casas, J.; Enrich, C.; Garcia-Ruiz, C.; Fernández-Checa, J. C..
Redox Biol. 2017, 11, 60–72.
- Dihydroceramide Desaturase Inhibitors Induce Autophagy via Dihydroceramide-Dependent and Independent Mechanisms.-
Casasampere, M.; Ordóñez, Y. F.; Casas, J.; Fabrias, G.
Biochim. Biophys. Acta – Gen. Subj. 2017, 1861 (2), 264–275.
- Dihydroceramide Accumulation Mediates Aytotoxic Autophagy of Cancer Cells via Autolysosome Destabilization.-
Hernández-Tiedra, S.; Fabriàs, G.; Dávila, D.; Salanueva, Í. J.; Casas, J.; Montes, L. R.; Antón, Z.; García-Taboada, E.; Salazar, M.; Lorente, M.; Nylandsted, J.; Armstrong, J.; López-Valero, I.; McKee, C. S.; Serrano-Puebla, A.; García-López, R.; González- Martínez, J.; Abad, J. L.; Hanada, K.; Boya, P.; Goñi, F. M.; Guzmán, M.; Lovat, P.; Jäättelä, M.; Alonso, A.; Velasco, G.
Autophagy 2016, 12(11), 2213-2229.
- Bacterial versus Human Sphingosine-1-Phosphate Lyase (S1PL) in the Design of Potential S1PL Inhibitors.-
Sanllehí, P.; Abad, J.-L.; Casas, J.; Bujons, J.; Delgado, A.
Bioorg. Med. Chem. 2016, 24 (18), 4381–4389.
- Exploring the Disruptive Effects of TBT on Lipid Homeostasis of Daphnia Magna Using Chemometric Methods.-
Malik, A.; Jordao, R.; Campos, B.; Casas, J.; Barata, C.; Tauler, R.
Chemom. Intell. Lab. Syst. 2016, 159, 58–68.
- Studies on the Inhibition of Sphingosine-1-Phosphate Lyase by Stabilized Reaction Intermediates and Stereodefined Azido Phosphates.-
Sanllehí, P.; Abad, J.-L.; Bujons, J.; Casas, J.; Delgado, A.
Eur. J. Med. Chem. 2016, 123, 905–915.
- Signorelli, P. Inhibition of Ceramide de Novo Synthesis as a Postischemic Strategy to Reduce Myocardial Reperfusion Injury.-
Reforgiato, M. R.; Milano, G.; Fabriàs, G.; Casas, J.; Gasco, P.; Paroni, R.; Samaja, M.; Ghidoni, R.; Caretti, A.
Basic Res. Cardiol. 2016, 111 (2), 12
- Inhibitors of Dihydroceramide Desaturase 1: Therapeutic Agents and Pharmacological Tools to Decipher the Role of Dihydroceramides in Cell Biology.-
Casasampere, M.; Ordoñez, Y. F.; Pou, A.; Casas, J.
Chem. Phys. Lipids 2016, 197, 33–44.
- Sphingolipids as Mediators in the Crosstalk between Microbiota and Intestinal Cells: Implications for Inflammatory Bowel Disease-
Phillips-Farfán, B.; Carvajal, K.; Medina-Torres, E.-A.; Espinosa-Padilla, S.-E.; Fabriàs, G.; Camacho, L..
Mediators Inflamm. 2016, 2016, 1–11.
- Investigation of Original Multivalent Iminosugars as Pharmacological Chaperones for the Treatment of Gaucher Disease.-
Laigre, E.; Hazelard, D.; Casas, J.; Serra-Vinardell, J.; Michelakakis, H.; Mavridou, I.; Aerts, J. F. G.; Delgado, A.; Compain, P.
Carbohydr. Res. 2016, 429, 98–104.
- Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd Edition).-
Klionsky, D. J.; et al.
Autophagy. 2016;12(1):1-222.
- 3- Ketosphinganine Provokes the Accumulation of Dihydroshingolipids and Induces Autophagy in Cancer Cells.-
Ordoñez, Y. F.; Gonzalez, J.; Abad, J. L.; Bedia, C.; Casas, J.; Delgado, A.; Fabrias, G.
Mol. BioSyst. 2016, 12, 1166–1173.
- Approaches to Polyunsaturated Sphingolipids: New Conformationally Restrained Analogs with Minimal Structural Modifications.-
Nieves, I.; Abad, J.-L.; Montes, L. R.; Goñi, F. M.; Delgado, A.
Tetrahedron 2016, 72 (5), 605–612.
- Therapeutic Potential of the Modulation of Sphingosine-1-Phosphate Receptors.-
Delgado, A.; Martínez-Cartró, M.
Curr. Med. Chem. 2016, 23 (3), 242–264.
- Ceramide Synthases in Biomedical Research.-
Cingolani, F.; Futerman, A. H.; Casas, J.
Chem. Phys. Lipids 2016, 197, 25–32.
- Inhibitors of Sphingosine-1-Phosphate Metabolism (Sphingosine Kinases and Sphingosine-1-Phosphate Lyase).-
Sanllehí, P.; Abad, J. L.; Casas, J.; Delgado, A.
Chem. Phys. Lipids 2016, 197, 69–81.
- Activity of Neutral and Alkaline Ceramidases on Fluorogenic N -Acylated Coumarin-Containing Aminodiols.-
Casasampere, M.; Camacho, L.; Cingolani, F.; Casas, J.; Egido-Gabás, M.; Abad, J. L.; Bedia, C.; Xu, R.; Wang, K.; Canals, D.; Hannun, Y. a.; Mao, C.; Fabrias, G
J.Lipid Res. 2015, 56 (10), 2019–2028.
- Azide-Tagged Sphingolipids: New Tools for Metabolic Flux Analysis.-
Garrido, M.; Abad, J. L.; Fabrias, G.; Casas, J.; Delgado, A.
ChemBioChem 2015, 16 (4), 641–650
- Coordinated Regulation of the Orosomucoid-like Gene Family Expression Controls de Novo Ceramide Synthesis in Mammalian Cells-
Kiefer, K.; Carreras-Sureda, A.; García-López, R.; Rubio-Moscardó, F.; Casas, J.; Fabriàs, G.; Vicente, R..
J.Biol. Chem. 2015, 290 (5), 2822–2830
- Chemical Probes of Sphingolipid Metabolizing Enzymes.-
Nieves, I.; Sanllehí, P.; Abad, J.-L. L.; Fabriàs, G.; Casas, J.; Delgado, A.
Bioactive Sphingolipids in Cancer Biology and Therapy; Hannun, Y., Luberto, C., Obeid, L., Mao, C., Eds.; Springer International Publishing: Cham, 2015; pp 437–469.
- A Straightforward Synthesis of the CERT Inhibitor (1′R,3′S)-HPA-12. Abad, J.-L.; Armero, I.; Delgado, A.-
Tetrahedron Lett. 2015, 56 (13), 1706–1708.
- Fluorescent Polyene Ceramide Analogues as Membrane Probes.-
Nieves, I.; Artetxe, I.; Abad, J. L.; Alonso, A.; Busto, J. V; Fajari, L.; Montes, L. R.; Sot, J.; Delgado, A.; Goni, F. M.
Langmuir 2015, 31, 2484–2492.
- Selective Chaperone Effect of Aminocyclitol Derivatives on G202R and Other Mutant Glucocerebrosidases Causing Gaucher Disease.-
Serra-Vinardell, J.; Díaz, L.; Guitiérrez-de Terán, H.; Sánchez-Ollé, G.; Bujons, J.; Michelakakis, H.; Mavridou, I.; Aerts, J. M. F. G.; Delgado, A.; Grinberg, D.; Vilageliu, L.; Casas, J.
Int. J. Biochem. Cell Biol. 2014, 54, 245–254.
- On-Tissue Localization of Ceramides and Other Sphingolipids by MALDI Mass Spectrometry Imaging.-
Jones, E. E.; Dworski, S.; Canals, D.; Casas, J.; Fabrias, G.; Schoenling, D.; Levade, T.; Denlinger, C.; Hannun, Y. A.; Medin, J. A.; Drake, R. R.
Anal. Chem. (Washington, DC, United States) 2014, 86 (16), 8303–8311.
- Inhibition of Dihydroceramide Desaturase Activity by the Sphingosine Kinase Inhibitor SKI II.-
Cingolani, F.; Casasampere, M.; Sanllehí, P.; Casas, J.; Bujons, J.; Fabrias, G.
J.Lipid Res. 2014, 55 (8), 1711–1720.
- Molecular Cloning and Knockdown of Galactocerebrosidase in Zebrafish: New Insights into the Pathogenesis of Krabbe’s Disease-
Zizioli, D.; Guarienti, M.; Tobia, C.; Gariano, G.; Borsani, G.; Bresciani, R.; Ronca, R.; Giacopuzzi, E.; Preti, A.; Gaudenzi, G.; Belleri, M.; Di Salle, E.; Fabrias, G.; Casas, J.; Ribatti, D.; Monti, E.; Presta, M.
Biochim. Biophys. Acta 2014, 1–11.
- Anti-Inflammatory Action of Lipid Nanocarrier-Delivered Myriocin: Therapeutic Potential in Cystic Fibrosis-
Caretti, A.; Bragonzi, A.; Facchini, M.; De Fino, I.; Riva, C.; Gasco, P.; Musicanti, C.; Casas, J.; Fabrias, G.; Ghidoni, R.; Signorelli, P.
Biochim. Biophys. Acta, Gen. Subj. 2014, 1840 (1), 586–594.
- Glucocerebrosidase Enhancers for Selected Gaucher Disease Genotypes by Modification of α-1-C-Substituted Imino-D-Xylitols (DIXs) by Click Chemistry.-
Serra-Vinardell, J.; Díaz, L.; Casas, J.; Grinberg, D.; Vilageliu, L.; Michelakakis, H.; Mavridou, I.; Aerts, J. M. F. G.; Decroocq, C.; Compain, P.; Delgado, A.
ChemMedChem 2014, 9, 1744–1754.
- Mechanistic Studies on the Intramolecular Cyclization of O-Tosyl Phytosphingosines to Jaspines.-
Crehuet, R.; Mormeneo, D.; Anglada, J. M.; Delgado, A.
Nat. Prod. Commun. 2014, 9 (8), 1087–1090.
- Evaluación del papel de la cert en el cáncer de mama mediante silenciadores químicos innovadores dirigidos al proteasoma.-
Coordinator: Gemma Fabriàs
Grant: PID2020-113813RB-I00 funded by MCIN/ AEI/10.13039/501100011033
Period: 2021-2024
Funding: 246.965,00
- Mejora de la caracterización de mezclas complejas por estectrometría de masas con de movilidad iónica cíclica.-
Coordinator: Josefina Casas Brugulat
Grant: EQC2021-007058-P funded by MCIN/AEI/10.13039/501100011033 y por la Unión Europea Next GenerationEU/ PRTR
Period: 2021-2023
Funding: 1.041.202,52
