Molecular Links between Diabetes & Neurodegenerative Diseases

Molecular Links between Diabetes & Neurodegenerative Diseases



Alzheimer's disease, Parkinson's disease, sporadic inclusion body myositis, Lafora disease and Gaucher disease are age-related degenerative diseases increasing in worldwide prevalence due to population ageing, improved diagnostic and changes in lifestyle. Substantial epidemiological evidence and data from animal models show co-morbidity among these diseases and type-2 diabetes. However, the underlying biological mechanisms that link the development of (neuro)degeneration and metabolic disturbances are not fully understood. Aberrant protein processing and accumulation in pancreatic islets, brain cells and/or skeletal muscle, abnormalities in insulin signalling, deregulated glucose metabolism, mitochondrial dysfunction and increased oxidative stress, the formation of advanced glycation end products, and the activation of inflammatory pathways are features common to most of these diseases.

In this project a consortium of research groups with leading expertise in relevant clinical, basic and applied aspects of diabetes and highly-prevalent and rare neurodegenerative diseases, as well as in the development of advanced platforms for human disease modelling, early diagnosis and treatment have been put together. The combined effort will allow the systematic interrogation of genuinely human disease models to identify interacting pathogenic mechanisms linking diabetes and neurodegeneration, which will be further used as targets for novel therapeutic strategies and early diagnosis devices.
Partners
  • Centre for Regenerative Medicine in Barcelona (CRMB)
  • CIBERDEM
  • CIBERNED
  • CIBERER

Participating Investigators
Funding
Instituto de Salud Carlos III - Proyectos Integrados de Excelencia. Convocatoria 2014 de la Acción Estratégica en Salud 2013-2016.

Duration: 2015-2017
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