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Synthetic Tubular Molecules Mimicking the Function of Channel Proteins


Jun-Li Hou

Department of Chemistry, Fudan University

July 19th  12:00 h

 In natural systems, channel proteins are responsible for the processing of ion and molecular inputs and exports, sensing environmental stimuli and signals across cell membranes. Because of the important function of channel proteins, chemists proposed to construct artificial systems to mimick the function of the channel proteins, which might help us on understanding the transport mechanisms, creating materials for separation, and developing therapeutic agents.We are interested in the construction of confined unimolecular tubular channels by considering their predictable conformation, high capacity of inserting into lipid bilayers. By using the rigid and symmetric pillar structure of pillararene, we have constructed a series of synthetic tubular molecules which have displayed unique properties for selective transmembrane transport of proton, water, amino acids, and voltage-gated and uphill transport of K+. By further precise modification of the channel structure, we have also achieved the selective recognition of the bilayer membrane of Gram-positive bacteria, which led to the high antimicrobial activity.

 

Seminari IQAC

Nanoparticles as contrast agents with a focus on 19F-MRI


Mónica Carril

CIC BiomaGUNE, San Sebastián, Spain

14th July 12.00h

In the last decades, nanotechnology has widely contributed to the field of preclinical contrast-enhanced imaging, and nowadays nanoparticles (NPs) as imaging probes are ubiquitous in MRI studies, among other imaging technologies. Fluorine 19 (19F) based MRI is a re-emerging field with promising features which complement proton-based traditional MRI. The most interesting advantage of 19F over 1H is the negligible endogenous 19F-MRI signal, for which any detectable signal can only come from an exogenous probe. However, in order to achieve a quality of image similar to that obtained with conventional MRI, a high load of fluorine atoms with the same resonance frequency is required. One of the main challenges in this field at the moment is the improvement of existing contrast agents in order to increase the SNR and circumvent the intrinsic hydrophobicity of fluorinated probes. Taking this into account, the use of NPs bearing a high number of identical fluorinated ligands could be an appealing strategy to increase the local concentration of chemically equivalent fluorine atoms. In this context, novel fluorine labels for nanoparticles have been designed, synthesised, characterised and tested as potential imaging probes.

 

Seminari IQAC

Synthesis of nanoparticles and nanocomposites by nanoemulsion and semicontinuous heterophase polymerization processes


Jorge E. Puig
Departamento de Ingeniería Química, UNIVERSIDAD DE GUADALAJARA, GUADALAJARA, MÉXICO


13 de  juny a la Sala d'Actes a les 11 hores

 

Seminari de l'IQAC

Theoretical study of heterogeneous photocatalysis:

Water oxidation on TiO2 under ultra-high vacuum conditions

Annapaola Migani


Institute of Advanced Chemistry of Catalonia (IQAC), CSIC
Department of Biological Chemistry and Molecular Modelling
Theoretical and Computational Chemistry Group
 

Dijous, 1 de Juny de 2017, a les 12:00 h. Saló d’Actes del CID

 

Seminaris "El futur científic de l'IQAC"

Dr. Carles Rodríguez Escrich, ICIQ. Divendres 24 de febrer a les 12:00.

Dr. Agustí Lledó Ponsati, Universitat de Girona. Divendres 7 d'Abril a les 12:00.

Dr. Xavier Rovira Algans, Universitat de Vic. Dijous 21 d'Abril a les 12:00

Dra. Núria Rubio, IQAC. Dijous 16 de Març a les 12:00.

Totes les conferencies seran al saló d'Actes del CID.
 


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