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Nanoparticles as contrast agents with a focus on 19F-MRI

Mónica Carril

CIC BiomaGUNE, San Sebastián, Spain

14th July 12.00h

In the last decades, nanotechnology has widely contributed to the field of preclinical contrast-enhanced imaging, and nowadays nanoparticles (NPs) as imaging probes are ubiquitous in MRI studies, among other imaging technologies. Fluorine 19 (19F) based MRI is a re-emerging field with promising features which complement proton-based traditional MRI. The most interesting advantage of 19F over 1H is the negligible endogenous 19F-MRI signal, for which any detectable signal can only come from an exogenous probe. However, in order to achieve a quality of image similar to that obtained with conventional MRI, a high load of fluorine atoms with the same resonance frequency is required. One of the main challenges in this field at the moment is the improvement of existing contrast agents in order to increase the SNR and circumvent the intrinsic hydrophobicity of fluorinated probes. Taking this into account, the use of NPs bearing a high number of identical fluorinated ligands could be an appealing strategy to increase the local concentration of chemically equivalent fluorine atoms. In this context, novel fluorine labels for nanoparticles have been designed, synthesised, characterised and tested as potential imaging probes.